Hepatoprotective Activity of Ethanol Extract of Cleome rutidosperma Aerial Parts against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 3
Abstract
Cleome rutidosperma, Linn (Family-Cleomaceae) is claimed to relieve earache,pain.However thorough literature survey indicated that different plants of the same genus available in tropical parts of India have various reported biological activities like antifungal activity ,antibacterial activity analgesics, antipyretic, anthelmintic activity, antimycobacterial activity and cytotoxic activity and CNS depressant activity etc. Hepatoprotective activity has been reported on some other plants of Cleome genus. Thus with an assumption that, the plant Cleome rutidosperma might have similar hepatoprotective activity ,the ethanolic extract of aerial parts of Cleome rutidosperma was investigated for the said activity. It was found that the ethanol extract of a dose of 400 mg/kg body weight exhibited moderate protective effect by lowering the serum levels of alanine aminotransferase (ALT) or Serum Glutamate Pyruvate Transaminase (SGPT), aspartate aminotransferase (AST) or Serum Glutamate Oxaloacetate Transaminase (SGOT) andcholesterol to a significant extent. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of carbon tetrachloride treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by CCl4 and blood samples from the animals treated with the methanol extracts of Cleome rutidosperma showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells, the extracts of four above plants could afford significant dose-dependent protection against CCl4 induced hepatocellular injury. Keywords: Cleome rutidosperma, Hepatoprotective activity, Carbon tetrachloride
Authors and Affiliations
Anuradha. Khuntia, Sujit Kumar Mohanty, M. Sai Harika
Keywords
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