Hepatoprotective activity of Mentha arvensis Linn. leaves against CCL4 induced liver damage in rats
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To study the Hepatoprotective activity of ethanol, chloroform and aqueous extracts of Mentha arvensis leaves against CCL4 induced liver damage in rats. Methods: Hepatotoxicity was induced by CCL4 and the biochemical parameters such as serum glutamate pyruvate transminase (sGPT), serum glutamate oxaloacetate transaminase (sGOT), alkaline phosphatase (sALP), serum bilirubin (sB) and histopathological changes in liver were studied along with silymarin as standard Hepatoprotective agents. Results: The Phytochemical investigation of the extracts showed presence of flavonoids, steroids, triterpenoids, alkaloids, glycosides, carbohydrates, tannins, phenolic compounds. Treatment of the rats with chloroform, ethanol and aqueous extract with CCL 4 administration caused a significant reduction in the values of sGOT, sGPT, sALP and sB (P<0.01) almost comparable to the silymarin. The Hepatoprotective was confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusions: From the results it can be concluded that Mentha arvensis possesses Hepatoprotective effect against CCL4 induced liver damage in rats.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP233216
- DOI 10.1016/S2222-1808(12)60156-X
- Views 90
- Downloads 0
A bibliometric analysis of global Angiostrongylus cantonensis research
No
Primary tuberculosis of the glans penis-a rare case report
A 36 year old man was diagnosed with tuberculosis of glans penis. The patient was positive to Mantoux test and Ziehl-Neelsen staining of the exuding pus from penile lesion. The antitubercular regimen of directly observed...
School-based combined mass drug administration for soil-transmitted helminthiases and schistosomiasis among school-age children: lessons from two co-endemic areas in the Philippines
Objective: To demonstrate the safety and feasibility of school-based combined mass drug administration (MDA) using albendazole and praziquantel in selected areas in the Philippines. Methods: This study consisted of two p...
Current trends in the management of Ebola virus disease-an updated systematic review
The Ebola virus created a ripple of fear when its number of cases rose rapidly and drastically in recent years. Ebola infection is transmitted in humans when contact closely with blood, organs or other body fluids of inf...
The correlation between platelet count and parasite density in children with malaria infection
Objective: To assess the correlation between platelet count and parasite density. Methods: A cross-sectional study of febrile children was conducted in Batubara Regency, North Sumatra, Indonesia. We used rapid diagnostic...