Abstract

Objective: Liver diseases are a large public health problem in the world. Hence, herbal drugs have become increasingly popular and their use is widespread. The present study was carried out to hepatoprotective activity of 60% methanolic leaves and roots extract of Spilanthes radicans on carbontetrachloride induced hepatotoxicity in albino rats. Materials and methods: The 60% methanolic extract of S. radicans leaves and roots at a dose of 500 mg/kg were administered to albino rats per orally for five days. Hepatotoxicity was induced in albino rats by carbontetrachloride administration by subcutaneous on 2nd and 3rd day of treatment. The results of the rats treated with leaves and roots extract of S. radicans were compared with silymarin. Biochemical parameters such as serum SGPT, SGOT, ALP, ACP, direct bilirubin and total bilirubin were estimated to assess the liver functions by semi-autoanlyser using standard biochemical kits. Results: It was found that 60% methanolic leaves and roots extract at a dose of 500 mg/kg exhibited protective effect against hepatotoxicity in rats. The extract shows significant (p>0.01) reduction of SGPT, SGOT, ALP, ACP, Total and direct bilirubin levels compared to CCl4 treated rats. The hepatoprotective activity was furthermore supported by histopathological studies of liver tissue. Conclusion: The study indicates that 60% methanolic extract of S. radicans root exhibits potent hepatoprotective activity than S. radicans leaf.

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