Hepatoprotective Effects of Thymus and Salvia Essential oils on Paracetamol-Induced Toxicity in Rats
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2013, Vol 3, Issue 2
Abstract
Medicinal plants have been used traditionally worldwide for the prevention and treatment of liver disease. Thymus Capitatus and Salvia Officinal are used frequently as spices. The present investigation aimed to investigate the possible potential protective effect of Thymus and Salvia essential oils against Paracetamol induced hepatotoxicy. Administration of Paracetamol (500 mg/kg.b.wt) resulted in liver damage as manifested by significant increase in serum and hepatic lactate dehydrogenase (LDH) activity with a significant decrease in blood and hepatic glutathione (GSH) levels, as well as blood and hepatic superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities. Rats pretreated orally with essential oil of Thymus Capitatus and Salvia Officinal (50 mg/kg b. wt. daily) for 15 days then intoxicated with paracetamol showed a significant protection against-induced increase in serum and hepatic LDH activities and inhibit reduce GSH levels and enhance increase SOD and GPx activities in blood and liver. These data indicate that essential oils of Thymus Capitatus and Salvia Officinalis possessed a hepatoprotective activity against hepatotoxicity induced by paracetamol model due to their antioxidant activity.
Authors and Affiliations
H. El-Banna , M. Soliman , N. Al-wabel
Keywords
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