Hepatoprotective models and screening methods: a review
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 9
Abstract
Liver, the largest organ in the body is being evolved to maintain the body’s internal milieu and also protect itself from the challenges it faces during its implementation. It is a essential organ having assorted functions. It theater a significant position not only in the metabolism, production and storage other than in the detoxification of a lot of endogenous and exogenous compounds and converting them to less toxic substances for excretion. A number of herbal preparations are available in the market Liver cell injury caused by a range of toxic chemicals (certain chemotherapeutic agents, anti-biotic, carbon tetrachloride (CCL4), paracetamol (PCM), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. The present review is aimed on liver, its function, liver diseases, types of drug induced hepatotoxicity and their mechanisms of liver damage and clinical scenario.
Authors and Affiliations
Rajesh Asija| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Vijay Kumar| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Pravesh Kumar Sharma| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Radheshyam kumawat| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Aakash Yadav| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India.
DIET PLAN FOR MIGRAINE PATIENTS
Migraines without aura are characterized by sudden onset and can have a major impact on the sufferer’s daily life3. On average, untreated migraine episodes last from 4 to 72 hours4. A migraine with aura involves any numb...
Transdermal drug delivery system: - a review on transdermal patch
The main advantage of Transdermal drug delivery system is to bypass the first pass metabolism, avertance of the risk and annoyance of intravenous therapy and of the varied conditions of absorption, like pH changes, gastr...
An open label observational study for Drug adherence in Type 2 Diabetes Mellitus patients
Diabetes mellitus is a heterogeneous group of disorders characterized by abnormalities in carbohydrate, protein, and lipid metabolism. The central disturbance in diabetes mellitus is an abnormality in insulin production...
Dendrimer as a carrier for ocular drug delivery
The foremost challenges face by today’s researcher is ocular drug delivery. Delivery of drug to the targeted ocular tissue is restricted by various ocular barriers. To conquer the ocular drug delivery barriers and get be...
GREEN CHEMISTRY AS ZERO WASTE ALLIANCE
Green chemistry consists of chemicals and chemical processes designed to reduce or eliminate negative environmental impacts. The use and production of these chemicals may involve reduced waste products, non-toxic compon...