Hepcidin and Erythropoietin Level in Sickle Cell Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 8, Issue 3
Abstract
Background: Sickle cell anaemia is an inherited disorder in which the red blood cells become rigid and sticky, and change from being disc-shaped to being crescent-shaped. The change in shape is as a result of an abnormal form of haemoglobin which leads to damage of some organs. Aim: The study was carried out to determine the levels of hepcidin and erythropoietin in sickle cell anemia. Materials and Methods: Thirty confirmed sickle cell patients in steady state (HbSS-SS) and thirty persons with normal hemoglobin (HbAA) between the ages of 15 to 30 years were selected in this study. Results: The results obtained showed that the levels of hepcidinin sickle cell anaemia patients were significantly elevated when compared with normal haemoglobin (HbAA) (P<0.05). However, the levels of erythropoietin were significantly decreased in sickle cell anaemia stable state when compared to HbAA subjects (P<0.05). Conclusion: This could probably imply that the elevation in hepcidin affect level of erythropoietin negatively. Therefore, it is possible that an antihepcidin could be developed as a therapeutic tool in sickle cell anaemia.
Authors and Affiliations
Johnkennedy Nnodim, Udujih Bernard Uche, Udujih Helen Ifeoma, Nwaokoro Joakin Chidozie, Obeagu Emmanuel Ifeanyi, Aloy-Amadi Oluchi
Keywords
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- EP ID EP347643
- DOI 10.9734/BJMMR/2015/17480
- Views 78
- Downloads 0
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