HER2/neu Expression in Gastric and Esophagogastric Junction Adenocarcinoma
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Background: Gastric cancer is one of the most commonly diagnosed cancer and one of the most common causes of cancer-related deaths worldwide. HER-2/neu, a well-recognized factor, is indicated in the development of certain human solid tumors, notably breast cancer. High expression of HER2/neu has correlated with poor prognosis. Studies reveal combination of treatment with antibody targeting HER-2/neu protein (Trastuzumab) and chemotherapy significantly improves overall survival in patients with gastric and esophagogastric junctional (EGJ) adenocarcinomas with HER-2/neu protein overexpression. We aimed to investigate the frequency of Her2/neu expression and association with clinicopathological parameters in our gastric and EGJ adenocarcinoma series to make a contribution to the emerging data on this oncogene. Materials and Methods: A total of 100 cases, including biopsy and resection specimens between November 2012 and December 2014, were selected. Her2/neu expression was determined by immunohistochemistry (IHC) on tumor tissues. Samples with IHC 2+ scores/equivocal cases were tested using fluorescent in situ hybridization (FISH). Result: We found 8% positivity for HER2/neu protein expression (IHC 3+ and IHC 2+/FISH +). Gene amplification in 5 cases revealed 100% concordance with IHC 3+. The findings of our study are in concordance with international data. We also observed a relationship of intestinal phenotype, EGJ tumors, and well-differentiated adenocarcinoma with HER2 overexpression. Conclusion: The findings of our study suggest a relationship of EGJ tumors, intestinal phenotype, and well-differentiated adenocarcinoma with HER2 overexpression.
Authors and Affiliations
N Sunitha, G Champaka, Rekha V Kumar, K C Lakshmaiah
Keywords
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