HER2/neu Expression in Gastric and Esophagogastric Junction Adenocarcinoma
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Background: Gastric cancer is one of the most commonly diagnosed cancer and one of the most common causes of cancer-related deaths worldwide. HER-2/neu, a well-recognized factor, is indicated in the development of certain human solid tumors, notably breast cancer. High expression of HER2/neu has correlated with poor prognosis. Studies reveal combination of treatment with antibody targeting HER-2/neu protein (Trastuzumab) and chemotherapy significantly improves overall survival in patients with gastric and esophagogastric junctional (EGJ) adenocarcinomas with HER-2/neu protein overexpression. We aimed to investigate the frequency of Her2/neu expression and association with clinicopathological parameters in our gastric and EGJ adenocarcinoma series to make a contribution to the emerging data on this oncogene. Materials and Methods: A total of 100 cases, including biopsy and resection specimens between November 2012 and December 2014, were selected. Her2/neu expression was determined by immunohistochemistry (IHC) on tumor tissues. Samples with IHC 2+ scores/equivocal cases were tested using fluorescent in situ hybridization (FISH). Result: We found 8% positivity for HER2/neu protein expression (IHC 3+ and IHC 2+/FISH +). Gene amplification in 5 cases revealed 100% concordance with IHC 3+. The findings of our study are in concordance with international data. We also observed a relationship of intestinal phenotype, EGJ tumors, and well-differentiated adenocarcinoma with HER2 overexpression. Conclusion: The findings of our study suggest a relationship of EGJ tumors, intestinal phenotype, and well-differentiated adenocarcinoma with HER2 overexpression.
Authors and Affiliations
N Sunitha, G Champaka, Rekha V Kumar, K C Lakshmaiah
Keywords
Related Articles
- EP ID EP468613
- DOI -
- Views 112
- Downloads 0
Pancreatic Trauma - A Management Conundrum, whether to Operate or Not to Operate and Management of Complications: A Study from a Tertiary Care Hospital in South India
Introduction: Abdominal trauma has become one of the leading causes of mortality and morbidity around the world. There is much confusion about the management of pancreatic trauma. We present our data on the management of...
Three-dimensional Echocardiography: A Novel Technique for Rheumatic Mitral Valve Stenosis Evaluation
Introduction: This study aimed to assess which echocardiographic method has the best agreement with the mitral valve area (MVA) invasively evaluated by the Gorlin’s formula and also to evaluate the feasibility and reprod...
A Radiology-pathological Correlation of Renal Cell Carcinoma in a Tertiary Care Hospital - A Retrospective Study
Introduction: This study was conducted to understand the clinical algorithm of renal cell carcinoma (RCC). Correlation was done by a clinical presentation with radiological features and histopathology of RCC. The stress...
Cranial Anthropometric Indices in Population of Rajasthan, India
Background: Width and length of bones of both face and skull is increased by the post-natal craniofacial growth and development. By measuring these changes, classifi cation system of cranial and facial parameters can be...
Pattern of Refractive Errors and Disturbances of Binocular Vision in Medical College Students
Introduction: The present study is an attempt to work out the pattern of refractive errors and disturbances of binocular vision in 1265 medical college students, who are subjected to visual stress of higher education. Ma...