Hippocampus, hippocampal sclerosis and epilepsy.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 3
Abstract
Hippocampal sclerosis (HS) is considered one of the major pathogenic factors of drug-resistant temporal lobe epilepsy. HS is characterized by selective loss of pyramidal neurons - especially of sectors CA1 and CA3 of the hippocampus - pathological proliferation of interneuron networks, and severe glia reaction. These changes occur in the course of long-term and complex epileptogenesis. The authors, on the basis of a review of the literature and own experience, present the pathomechanisms leading to hippocampal sclerosis and epileptogenesis, including various morphological and functional elements of this structure of the brain and pharmacological possibilities of preventing these processes.
Authors and Affiliations
Krzysztof Sendrowski, Wojciech Sobaniec
Keywords
Related Articles
- EP ID EP151635
- DOI -
- Views 104
- Downloads 0
Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells.
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling. There is dual control of vascular ton...
Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers.
The compound MG-1(R,S), (1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, and its enantiomers were tested for electrocardiographic, antiarrhythmic and hypotensive activities. The racemic mixture (MG-1(R,S)...
Acute effect of ethanol on IgA immunoreactive cells in the intestine-associatedimmune system.
The purpose of this study was to investigate the acute effect of ethanolon mucosa-associated lymphoid tissue at the level of Peyer's patches and the intestinal lamina propriain female rats and to determine whether this a...
Type 2 diabetes mellitus: from genes to disease.
The development of type 2 diabetes (T2DM) is determined by two factors: genetics and environment. The genetic background of T2DM is undoubtedly heterogeneous. Most patients with T2DM exhibit two different defects: the im...
Amphetamine-induced effects on neuropeptide Y in the rat brain.
Repeated (+)-amphetamine sulfate (AMPH) administration (5 mg/kg sc twicedaily for 6 days and once on day 7) markedly and reversibly decreased (until 96 h after the final dose)neuropeptide Y-like immunoreactivity (NPY-LI)...