Histological And Biochemical Evaluation of the Effect of Topical Application of Curcumin And Propolis on oral Ulcer in Albino Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Abstract : Pro-inflammatory cytokines such as tumor necrosis factor alpha and interlukin -8 played a major role in pathogenesis of oral ulceration. Recently, considerable attention has been focused on using natural herbs as an effective treatment modality for many types of oral ulcers. Curcumin has potent anti- inflammatory properties. Propolis extract is a bee-metabolized resinous substance that exerts antioxidant, anti-inflammatory and analgesic effects. Aim of study: The present study was conducted to evaluate and compare the effect of topical application of curcumin and propolis on induced palatal ulcers in rats. Materials and methods: A total of 30 adult male Albino rats were divided into three groups: Group I (control group), Group II (curcumintreated group) and Group III (propolis-treated group). 5 rats from each group were sacrificed at day 2 and 8. Tissue samples were obtained and prepared for histological and biochemical evaluations. The data obtained were statistical analyzed and compared. Results: Curcumin and propolis treated group showed a significant reduction in TNF- α after 8 days compared with control group. While no significant difference was detected between curcumin and propolis groups. Regarding IL-8 level significant difference was seen between control group and curcumin after 8 days while, no significant difference was detected between control and propolis or between curcumin and propolis. Histological examination revealed reduction in inflammation, epithelial regeneration and formation of thick keratin layer in group I and II after 8 days with minimal number of inflammatory cells in curcumin group. Conclusion: we concluded that curcumin and propolis could be considered as a promising adjuvant treatment for oral ulcerations. However, curcumin is more effective than propolis
Authors and Affiliations
Soha Basha
Keywords
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- EP ID EP251549
- DOI 10.9790/0853-1612112631
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