HISTOPATHOLOGICAL CHANGES IN ADHATODA VASICA TREATED MICE STOMACH AFTER GAMMA-IRRADIATION.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 4
Abstract
In the present study, Adhatoda vasica extract administered and radiation induced changes in the stomach of Swiss Albino male mice were studied. Animals were divided into four groups: Group I containing normal mice served as control for each experimental stage, mice of Group II received oral administration of Adhatoda vasica extract.(900mg/kg body weight),mice of group III received oral administration of Adhatoda extract and were irradiated with 4Gy γ –rays, mice of group IV were irradiated with 4Gy γ-radiation. Adhatoda extract was adminstred orally to the animals (900mg/kg body weight) for a period of 28 days. After 7 days of extract administration mice were irradiated with 4 Gy γ-rays. 24 hours after irradiation mice were sacrificed by cervical dislocation. on days 7,14,21and 28. Excised tissue was fixed in 10% neutral formalin. Sections of 5μm thickness were stained with hematoxylin and eosin for histopathological examination. Histological changes in the mice stomach were observed between 7-28 days of investigation. Extract treated group of mice showed no alterations in the architecture of gastric mucosa. Mice which were pretreated with extract and then irradiated showed continuous mucosal layer and also disruption is minimized. In the irradiated group the damaged mucosal layer with lesions at different regions of mucosal lining i.e gastritis is pronounced. Gastric glands are disorganized showing large intracellular spaces. Muscularis mucosal slips become irregular.
Authors and Affiliations
Sushma Sharma| Department of Bio-Sciences, Himachal Pradesh University Summer Hill Shimla-171005, Himachal Pradesh India., Anupam Pundir| Department of Bio-Sciences, Himachal Pradesh University Summer Hill Shimla-171005, Himachal Pradesh India.
Keywords
Related Articles
- EP ID EP3741
- DOI -
- Views 418
- Downloads 18
STUDY OF THE KNOWLEDGE, ATTITUDE AND PRACTICES OF REFRACTIVE ERROR WITH EMPHASIS ON SPECTACLE USAGES IN STUDENTS OF RURAL CENTRAL INDIA.
Aim: To Study the knowledge, attitude and practices of refractive errors with emphasis on spectacle usages in students of rural central India. Background: Refractive error is the most common cause of blindness which ca...
ANAYTICAL METHOD DEVEOPMENT AND VAIDATION OF BUTYLATED HYDROXYTOLUENE IN ROSUVASTATIN TABLETS BY USING RP-HPLC
An RP-HPLC method was developed and validated for the estimation of Butylated Hydroxy toluene in Rosuvastatin Tablets. The chromatographic system was equipped with Hypersil BDS, C18, 250 X 4.6 mm, internal diameter with...
Demonstration the Expression of α-Methyl Acyl-Co EnzymeA Racemase, P63 and high- molecular-weight cytokeratin in Prostate biopsies in Khartoum State Hospitals
Prostate cancer is the major health problem throughout the world. PCa remains the most common malignancy affecting men and the second leading cause of cancer-related death of men. The immunohistochemistry plays a very im...
CURRENT NECESSITY OF PROTEASES: OVERVIEW
The use of proteases as medicine is also popular as the study of proteases has helped us better understands inflammatory conditions and immune regulation. If a protein (part of living cell) component including other nece...
LOW BIRTH WEIGHT-A HOSPITAL BASED CASE CONTROL STUDY
Birth weight has been defined by the World Health Organization as weighing less than 2,500 grams are approximately 20 times more likely to die than heavier babies.2 more common in developing than developed countries; a b...