Histopathological Study of the Architectural Patterns of in Situ Carcinoma in Cases of Invasive Breast Cancer
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 6
Abstract
Context: In situ carcinoma in breast can be studied at two levels: 1. different morphologic patterns 2. by utilizing a prognostic grading system like the Van Nuys system. This study would provide information regarding the patterns, classification, prognostic grading, also predict the risk of recurrence after excision and assist in selecting treatment options. Aims: • To estimate the cases displaying different architectural patterns of in situ carcinoma in invasive breast cancers. • Determination of prognostic index (Van Nuys) of in situ carcinoma based on these patterns. Methods and Material: A Cross sectional study of 40 Modified Radical Mastectomy specimens collected for a period of 18 months in our Tertiary care hospital. For histopathology study, specimens were fixed in 10% formalin, processed, paraffin embedded, sections (3-5 ì thickness) taken, stained with Haematoxylin and Eosin and studied under light microscope. Statistical analysis used: Continuous variables are expressed as mean ±SD whereas categorical variables are expressed as percentages. Data was analysed using SPSS version 20. P value < 0.0 was considered as statistically significant. Results: All architectural patterns of DCIS either single or mixed were present in the cases of invasive breast carcinoma, with solid [9 (36%) cases]: most common single architectural pattern and Solid and comedo [7 (47%) cases]: the most common mixed architectural pattern. High grade ductal carcinoma in situ was seen in 18 patients (45% of cases), intermediate grade in 17 patients (43%) and low grade was seen in 5 patients (12%). Conclusions: The current study provides evidence of the frequency of significant histologic heterogeneity of in situ carcinoma, with at least 2 different architectural patterns of ductal carcinoma in situ commonly present in individual lesions.
Authors and Affiliations
Apoorva A. N.
Keywords
Related Articles
- EP ID EP524118
- DOI 10.21088/ijprp.2278.148X.7618.8
- Views 85
- Downloads 0
Accuracy of Triple Assessment in Diagnosing Breast Cancer with Histopathological Correlation
Introduction: Breast cancer is the leading cause of death in females, whose meticulous evaluation is required for an early diagnosis. Aims and objectives: In our study we evaluated the role of triple assessment in diagno...
Histopathology of Endometrium in Patients Presenting with Abnormal Uterine Bleeding
Background: Abnormal uterine bleeding (AUB) is the most commonand challenging problems presenting to gynaecologists now-a-days. Any bleeding pattern deviated from normal menstrual cycle results in AUB. Aims and objectiv...
Comparison Study of Platelet Count Estimation by Two Methodologies: an Automated Hematologyanalyzer and Peripheral Blood Smear Examination
Introduction: Many diseases such as malaria, dengue, pyrexia of unknown origin, pregnancy-induced hypertension are associated with low platelet counts. Automated method is the most reliable method. It is simple, fast, an...
Bilateral Metachronous Breast Cancer
Introduction : Bilateral breast cancer is extremely rare presentation. Most of the cases of bilateral breast cancer are of lobular carcinoma type. Herewith we report a case of bilateral Invasive Breast Carcinoma (Not Oth...
Histopathological Study of Endometrial and Cervical Changes in Hysterectomy Specimens of Perimenopausal Age
Introduction: Numerous terminologies are used to describe abnormal uterine bleedingmenorrhagia, metrorrhagia, polymenorrhea, oligomenorrhea, intrmenstrual and postcoital bleeding [6]. The spectrum of cervical changes in...