Hormonal and Histomorphological impacts of Oral Mesterolone (Proviron) in Adult Male Sprague Dawley Rats’ Epididymes.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 3
Abstract
Concern has been expressed worldwide about Anabolic-androgenic steroids (AAS), one of the most widely abused drugs by athletes and muscle builders with gain to improving their performance and muscle mass in recent times. Moreover, AAS offer inappreciable benefits to infertile and sub-fertile males, with possible deleterious effects on both human and animal physiology including sperm quality. Due to the paucity of knowledge, the present study aimed to evaluate Mesterolone (AAS) impacts on adult male Sprague-Dawley rats’ epididymes using serum hormones and histomorphologic assessment. Twenty adult male Sprague Dawley rats divided into two groups of 10 each. The treated group received 0.06mg/ g body weight/ day of Mesterolone (Proviron) by oral gavage for forty-two days while the control group received the equal volume of 0.9% normal saline per day. SPSS analysis of data generated with P< 0.05 considered statistically significant. The result showed lower significant (P< 0.05) body weight gain in the Proviron group. However, the raw epididymal weight and relative epididymal weight per 100g bwt were both higher significantly (P< 0.05) in the Provirontreated than the control groups. Where as, T and FSH were significantly (P< 0.05) lowered in Proviron group than the control. Evidence of regressive changes with irregularly shaped tubules, tubular lumen dilatation, reduced epithelial height and basement were observed in the epididymes of Proviron-treated animals. Thus, Mesterolone usage has undesirable effects on the epididymes and short, intermittent therapy is advice for desirable outcomes.
Authors and Affiliations
Shittu, Lukeman A. J, Shittu, Remilekun. K, Jinadu, Abiodun M, Adesanya, Olamide A
Keywords
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