Abstract

Human papillomavirus (HPV) is a known cause of cervical cancers, as well as some vulvar, vaginal, penile, oropharyngeal, anal, and rectal cancers. Recently, CDC analyzed data from population-based cancer registries that participate in the CDC's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results program and met the criteria for high data quality for all years 2008 2012, covering approximately 99% of the U.S. population. It was estimated that approximately 30,700 new cancers were attributable to HPV, including 19,200 among females and 11,600 among males. Compared with a previous analysis, which reported 33,369 HPV-associated cancer cases diagnosed each year during 2004 2008, the results of this analysis demonstrate an overall increase in HPV-associated cancer incidence, from 10.8 per 100,000 persons during 2004 2008 to 11.7 per 100,000 persons during 2008 2012, despite a slight decrease in the rate of cervical carcinoma. Part of this increase is because of the inclusion of additional subsites for oropharyngeal cancer; however, the increase persisted when these subsites were excluded from analysis.

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