Human Epidermal Growth Factor Receptor-3 mRNA Expression as a Prognostic Marker for Invasive Duct Carcinoma not Otherwise Specified
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 2
Abstract
Introduction: Breast cancer is the most common cancer in women and the Erythroblastosis Oncogene B(ErbB) receptor family holds crucial role in its pathogenesis. Human Epidermal Growth Factor Receptor 3 (HER-3) gene over expression in breast tissue has been associated with aggressive clinical behaviour and bad prognosis. Aim: To evaluate HER-3 mRNA expression level as a prognostic marker for breast cancer and to correlate its level with other established prognostic parameters. Materials and Methods: This study was carried out on specimens of 100 cases that were divided into 40 patients presented with fibroadenoma and 60 patients presented with Invasive Ductal Carcinoma (IDC) not otherwise specified and underwent modified radical mastectomy. All specimens were investigated for HER-2/neu, ER and PR expression by Immunohistochemistry (IHC) and quantitative assay of HER-3 mRNA expression using real time PCR technique. Results: There was a significant high HER3 mRNA level in carcinoma cases compared to fibroadenoma. In malignant cases, HER3 mRNA level was significantly associated with advanced T stage, advanced N stage, number of positive lymph nodes, large tumour size and cases associated with an adjacent in situ component. Moreover, HER-3 mRNA level was of highest values in Her-2/neu positive group followed by triple negative cases with the lowest level in luminal group (p<0.05). Conclusion: HER-3 gene is upregulated in IDC especially those carrying poor prognostic features. HER-3 mRNA level may identify a subset of patients with a poor prognosis, and who could undergo further evaluation for the efficacy of HER3 targeted anticancer therapy
Authors and Affiliations
Ghada Ezat Hammoda, Sally Mohammed El-Hefnawy, Asmaa Gaber Abdou, Rania Abdallah Abdallah
Keywords
Related Articles
- EP ID EP333244
- DOI 10.7860/JCDR/2017/23812.9442
- Views 115
- Downloads 0
Rosai-Dorfman Disease: A Clinico-pathological Presentation of Three Cases and Review of Literature
ABSTRACT Rosai-Dorfman Disease (RDD) or Sinus Histiocytosis with Massive Lymphadenopathy (SHML) is a rare histiocytic disorder of unknown aetiology which presents as a benign, self-limiting disease of phagocytic histiocy...
Characterisation of Breast Cancer Lesions using Image Processing Based Technique
ABSTRACT Introduction: Characterisation of mammographs deliberates as influential approaches in cataloguing of breast tissues and tumour. In breast, unravelling of nearby tissues in the mammographs is one of the tough pr...
Comparative Analysis of Serum Levels of Total Carbohydrates and Protein Linked Carbohydrates in Normal and Diabetic Individuals
ABSTRACT Introduction: Non-enzymatic glycation and enzymatic glycosylation of proteins have been proposed as a major factor in the pathogenesis of diabetic complications by altering structure-function of proteins. Though...
Superior Vena Cava as Gateway to Heart: Metastatic Breast Carcinoma Causing Ball in a Loop Metastasis to Right Atrium
Breast carcinoma is the most common invasive cancer in women worldwide. It metastasizes commonly to bone, lungs, regional lymph nodes and brain. Cardiac metastasis of lung and breast cancers is a known but rare complicat...
Significance of Cytological Diagnosis in Benign Salivary Gland Lesion
ABSTRACT A diffuse, chronic, non-inflammatory, non-neoplastic usually bilateral, enlargement of major salivary glands is termed as Sialadenosis or sialosis. It is an uncommon cause for enlargement of the parotid gland. W...