Human Peripheral Blood Derived Hematopoietic Stem Cell: History, the Isolation Methods and Investigation of Different Parameters Effects on Their Differentiation to the Body Cells
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2014, Vol 2, Issue 2
Abstract
Blood and the system that forms it, known as the hematopoietic system, consist of many cell types with specialized functions. Red blood cells (erythrocytes) carry oxygen to the tissues. Platelets (derived from megakaryocytes) help prevent bleeding. Granulocytes (neutrophils, basophils and eosinophils) and macrophages (collectively known as myeloid cells) fight infections from bacteria, fungi, and other parasites such as nematodes (ubiquitous small worms). Some of these cells are also involved in tissue and bone remodeling and removal of dead cells. B-lymphocytes produce antibodies, while T-lymphocytes can directly kill or isolate by inflammation cells recognized as foreign to the body, including many virus-infected cells and cancer cells. Many blood cells are short-lived and need to be replenished continuously; the average human requires approximately one hundred billion new hematopoietic cells each day. The continued production of these cells depends directly on the presence of Hematopoietic Stem Cells (HSCs), the ultimate, and only, source of all these. Peripheral blood stem cells (PBSC) are rapidly becoming the primary rescue modality for autologous transplantation and are now actively being investigated in the allogeneic transplant setting. Many investigators and clinical researchers believe that PBSC are likely to replace bone marrow stem cells entirely, for use in clinical transplantation in the not too distant. Hematopoietic stem cells (HSCs) are the blood cells that give rise to all the other blood cells. They give rise to the myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has changed in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors.
Authors and Affiliations
Javad Mohammadnejad
Keywords
Related Articles
- EP ID EP195209
- DOI 10.19070/2328-3548-1400010
- Views 89
- Downloads 0
Ultrastructural Characterization of a Developing Pericytic Microtumor in the White Matter Post Laceration
We studied by transmission electron microscopy an intraparenchymatous mass within white matter found in a patient operated on for cerebral laceration. According to the ultrastructural criteria, this mass was diagnosed as...
The Use of Spermatogonial Stem Cells In Cancer-Induced Infertility
The Use of Spermatogonial Stem Cells In Cancer-Induced Infertility
Stem Cell Therapy in Liver Cirrhosis
Cirrhosis results from different mechanisms of liver injury that lead to necroinflammation and fibrogenesis; Patients with liver cirrhosis often require liver transplantation but it is affected by many problems, includin...
Multipotent Mesenchymal Stromal Cells Derived from the Bone Marrow Transported Over 12 Hours Change Their Main Characteristics
Multipotent Mesenchymal Stromal Cells Derived from the Bone Marrow Transported Over 12 Hours Change Their Main Characteristics
Investigation of Isolating of Human Mesenchymal Stem Cells From Umbilical Cord Blood and Labeling them with 99m Technetium
Tissue engineering through the imitation of nature has the ability to deal with the crisis caused by the shortage of donor organs and tissues. With regard to the ethical problems of extraction of embryonic stem cell, the...