Hyper IgE in a HIV Positive Patient - Case Report
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 1
Abstract
Background: Hyperimmunoglobulinemia E Syndrome (HIES) is a primary immunodeficiency syndrome associated with multiple abnormalities. Clinical manifestations of atopic allergy, drug reactions, and increased IgE in serum were previously reported during the course of human immunodeficiency virus (HIV) infection. Case report: We herby describe the case of one 63 yrs old male patient with a history of weight loss and diarrhoea, who was previously treated for enterocolitis. He was also treated at the Dermatological Clinic for herpes zoster infection and undiagnosed allergy. Microbiology tests showed presence of Candida and Klebsiella pneumoniae in the patient’s sputum which led to testing and confirmation of HIV/AIDS. After that, Lues was diagnosed and blood sample was sent to our laboratory, to evaluate if this atopic patients was sensitized to beta-lactam antibiotics. The results showed increased level of total IgE for almost 12 times above normal ranges and also allergy to ampicillin was revealed. Highly increased levels of total IgE indicated the possibility for HIE Syndrome in this patient. However the relationship of such findings to the immunologic abnormalities found in patients with HIV is not entirely clear. Conclusion:In conclusion, this is the first case of HIV positive patient with hyper IgE immunoglobulinemia in the Republic of Macedonia. We addressed the important laboratory findings and actual theories explaining possible association between hyper IgE immunoglobulinemia and HIV/AIDS.
Authors and Affiliations
Slavica Hristomanova| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Violeta Grunevska| University Clinic for Infective Diseases, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Maragareta Balabanova-Stefanova| University Clinic for Dermatovenerology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Dejan Trajkov| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Aleksandar Petlichkovski| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Meri Kirijas| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Eli Djulejic| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Aleksandar Senev| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Mirko Spiroski| Institut of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia
Keywords
Related Articles
- EP ID EP8793
- DOI 10.3889/MJMS.1857-5773.2011.0160
- Views 333
- Downloads 18
Combination of Left Ventricular Noncompaction and Bicuspid Aortic Valve in 19-Year-Old Male: A Case Report from Republic of Macedonia
Background: Noncompaction of the ventricular myocardium is a rare, unclassified cardiomyopathy due to an arrest of myocardial morphogenesis. The characteristic echocardiographic findings consist of multiple, prominent...
Maintenance Therapy with Rituximab in Adult Patients with Immune Thrombocytopenia
Immune thrombocytopenia (ITP) is an autoimmune disease of unknown etiology, characterized by isolated thrombocytopenia and the absence of any underlying cause for thrombocytopenia. Corticosteroids are the standard firs...
Noise Induced Sleep Disturbance in Adult Population: Cross Sectional Study in Skopje Urban Centre
Aim. To evaluate sleep disturbance caused by environmental noise in residents of Skopje urban centre and to quantify the probability for sleep disturbance related to night-time noise exposure. Methods. Cross sectional...
Audit of Premature Infants and Critically Ill Neonates Requiring Ex-Utero Transport by the First Macedonian Neonatal Emergency Transport Service: A Retrospective Descriptive Study
Background. Outcome for high-risk infants transferred in-utero is reported as better than the outcome of infants transferred after birth. Aim. The aim of this study is to present the first Macedonian neonatal emergency...
Plasma Adrenomedullin among Patients with Chronic Liver Diseases
Background. Adrenomedullin (AM) is a potent vasodilator peptide and it has been implicated as one of the mediator of the vasodilatory state in liver cirrhosis. Aim. The aim of the study was to determine the level of AM...