Abstract

Sickle cell disease (SCD) is the most common serious genetic disorder in Sudan; which characterized by red cells rigidity and abnormal viscoelasticity of cell membrane, that affect the plasma lipid profile. The aim of this study was to evaluate lipid profile in children with HbSS in Gaafer Ibn Oof children’s Hospital in Khartoum, Sudan. This case control study was done in 100 children; 50 of them were with sickle cell disease (HbSS) and another 50 were healthy children (HbAA), who were age and sex matched; served as control. The mean age of the children with SCD was (7.6±4.27years), versus (7.15±4.19 years) in control subjects. After overnight fasting; serum lipid profile was done using automated chemical analyzer. The mean triglycerides in SCD group was (151.6±5.6 mg/dl), versus (124.3±4.0 mg/dl); with P value (0.001), total cholesterol was (102.9±5.0mg/dl), versus (140.8±4.6mg/dl); with P value (0.000), HDL was (25.2±1.3mg/dl), versus (35.1±1.6 mg/dl); P value (0.000), LDL was (46.8±3.9 mg/dl), versus (54.6±1.5 mg/dl), VLDL was (30.3±1.3mg/dl) versus (24.9±0.8mg/dl) and atherogenic index was (1.21±0.55) versus (1.15±0.42); respectively. In SCD group; serum triglycerides significantly increased; while total cholesterol and high density lipoproteins significantly decreased. Conclusion: hypertriglyceridemia is predominant in Sudanese children with sickle cell disease; while total cholesterol and high density lipoproteins significantly reduce; these lipid abnormalities could represent a cardiovascular risk factor for the children with sickle cell disease.

Authors and Affiliations