HYPERURICAEMIA- AN INDEPENDENT PREDICTOR OF ACUTE STROKE AND ITS OPTIMAL LEVEL TO PREVENT STROKE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 44
Abstract
BACKGROUND Stroke ranks as a third most common cause of mortality in the world after ischaemic heart disease and malignancy in the elderly. The prevalence of hyperuricaemia in stroke is 35.2% in men and 8.7% in women in developing countries, and it is significantly higher in patients with acute stroke than the normal population. Serum uric acid role in stoke is controversial. Serum uric acid is a soluble pro-oxidant and antioxidant. Aim and Objectives- The present study aims to find serum uric acid levels in acute stroke patients and assess its relationship with other risk factors such as FBS, Lipid Profile, Hypertension, Alcohol, and Smoking and to find optimal level below which stroke can be prevented. MATERIALS AND METHODS In this case control study, we assessed a hundred patients with acute stroke (confirmed by CT and MRI Brain) who were admitted in MGMGH, Trichy, and hundred age and sex matched controls from November 2016 to January 2017. Patients with a known risk for cardioembolic disorders and hyperuricaemia were excluded from this study. Clinical records of patients, age and sex matched controls and their serum uric acid (Uricase Method), FBS (GOD-POD), Lipid Profile levels (Direct) were investigated. Finally, data were analysed using SPSS software 19. RESULTS Hundred acute stroke patients and controls were studied. Mean age of the patients was 56.2 ± 13.01 years. Mean serum uric acid level in stroke patients (6.07 ± 0.88) is higher than in control group (5.1 ± 0.93). There was a significant change of uric acid comparison between patients and control (P=0.001). There was no significant correlation between TGL, VLDL, FBS, Hypertension, Smoking and Alcohol between patients and control. P≤0.05 was considered significant. Uric acid is a significant risk factor for acute stroke. CONCLUSION Significant increase in serum uric acid level in patients with acute stroke indicates that it can be considered as an independent risk factor of acute stroke and management of hyperuricaemia and maintaining optimal level of below 5.2 mg% and 4.3 mg% in males and females can be useful to prevent stroke.
Authors and Affiliations
Arunraj Ezhumalai, Chandrakala Karuppasami, Ravikumar V
Keywords
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- EP ID EP215562
- DOI 10.14260/Jemds/2017/746
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