HYPOGLYCAEMIC ACTIVITY OF CENTRATHERUM ANTHELMINTICU IN EXPERIMENTAL ANIMALS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 4
Abstract
The Effect of Ethanolic extracts of Centratherum anthelminticum on Diabetic rats Assessment of the antihyperglycemic effect of ethanolic extract of Centratherum anthelminticum seeds in normal and alloxan induced diabetic rats: The animals will be divided into nine groups and each group consisted of six rats. Group 1 as normal control. Group 2 as the diabetic control. Groups 3, 4 and 5 are normally treated with 0.25 g, 0.50 g and 0.75 g/kg BW of CAEt, respectively. Groups 6, 7 and 8 are diabetic rats treated with 0.25 g, 0.50 g, and 0.75 g/kg BW of CAEt, respectively. Group 9 are diabetic rats which received glibenclamide (0.02 g/kg BW) an oral hypoglycemic agent dissolved in distilled water. Normal control and the diabetic control rats are fed distilled water alone. After an overnight fast, the plant extract suspended in distilled water will feed to the rats by gastric intubation using a force feeding needle. Blood samples are collected for the measurement of blood glucose from the tail vein at 0, 1, 2, 3, 4, 5 and 6 h after the administration of plant extract and blood glucose levels are determined by Glucose oxidase – peroxidase method. The phytochemical analysis will be carried out in the ethanolic extract by different methods of phytochemical analysis.
Authors and Affiliations
Ramji Swarnkar
Keywords
Related Articles
- EP ID EP293850
- DOI 10.22270/jddt.v7i4.1472
- Views 134
- Downloads 0
EVALUATION OF ANTI DIABETIC DRUG ALOGLIPTIN FOR THE TREATMENT OF OBESITY IN RATS
Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and environmental factors, which favors a chronic positive energy balance, and leads to increased body fat mass. The inci...
AWARENESS, RISK PERCEPTION AND PRACTICE OF SELF-MEDICATION AMONG PREGNANT WOMEN ATTENDING ANTE-NATAL CLINICS IN SOKOTO, NIGERIA
Background: In addition to its adverse health effects on mother and fetus, self-medication is believed to be one of the main driving forces behind the increasing burden of antimicrobial resistance worldwide. This study a...
VARIOUS HISTORICAL ASPECT OF COMMUNICABLE DISEASES DESCRIBED IN ANCIENT KALA OF VEDA AND SAMHITA
The development of medical system in India witnessed by all common era and the seeding of ancient ayurveda science starts from early development of civilization. The emergence of traditional medical system involves descr...
FORMULATION AND EVALUATION OF HERBAL LOZENGES
Throat infections are most common disease in today’s world. However, it is not taken too seriously by people. Long term throat infection can lead to severe throat problems like Pharyngitis and also cancer. Lozenges are s...
SURGERY CAN BE AVOIDED IN EXTRA OCULAR AND ORBITAL MYOCYSTICERCOSIS
Aim: To study the efficacy of Albendazole in treating Extra ocular and Orbital Myocysticercosis. Materials and Methods: This is a prospective interventional case study conducted at Department of Oculoplasty and Orbita...