Hypoglycemic Activity of Bridelia Stipularis on Combination of High Fat Diet and STZ Induced Diabetic Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
The aim of this study is to explore Bridelia stipularis which may lead to discovery of new therapeutic agents which may treat hyperglycemia and in future it may be used in diverse disease condition where hyperglycemia is the main source of amplifying and complication of other major disease processes. with the aim, the objectives of the study includes identification of active constituent which will be crucial in understanding the mechanism of action of the said activities and to evaluate the antidiabetic activity of the Bridelia stipularis leaf extract in HFD and STZ induced diabetic models. Sprague– Dawley (SD) rats (180–200 g) of either sex were allocated for dietary regimen of water and in house prepared high fat diet for two weeks. The HFD-fed rats exhibited significant increase in body weight, basal plasma glucose (PGL), triglycerides (PTG) and total cholesterol (PTC) levels. After 2 weeks of dietary manipulation, rats were injected intraperitoneally with low dose of streptozotocin (STZ) (35 mg kg−1). In addition, the levels of PTG and PTC were further accentuated after STZ treatment in HFD-fed rats. Thus, these fat-fed/STZ-treated rats simulate natural disease progression and metabolic characteristics typical of individuals at increased risk of developing type 2 diabetes because of insulin resistance and obesity. The present study represents that the combination of HFD-fed and low-dose STZtreated rat serves as an alternative animal model for type 2 diabetes and Bridelia stipularis can be used for treating hyper glycemia.
Authors and Affiliations
Geeta Basaiye
Keywords
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