HYPOGLYCEMIC ACTIVITY OF COPERNICIACERIFERA MART.L.EAF POWDER EXTRACT IN THE TREATMENT OF ALLOXAN-INDUCED DIABETIC MICE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 10
Abstract
Objective: This study characterizeesters from carnauba crude powder and evaluates its hypoglycemic effect on the treatment of diabetic animals.Methods: Groups of diabetic micewere induced by alloxan and treated with carnauba crude powder. Blood samples were collected to determine the glucose serum level.Results: The compound was identified and characterized as diester of the 4-methoxycinnamic acid (PCO-C) and presented hypoglycemic effect in the concentrations of 100 and 150 mg/kgbody weight (b.w. )The concentration 150 mg/kg b.w..o.f PCO-C presented the best effect on controlling glucose levels (p<0.05),when compared to the reference drug.Conclusion: The results indicate that the PCO-C is a promising therapeutic compound with hypoglycemic effect. This action can be justified by the presence of the diester of 4- methoxycinnamic acid.Â
Authors and Affiliations
Paula Alves Salmito Rodrigues, Izabel Florindo Guedes, MÃrcia Maria Mendes Marques, Isaac Neto Goes Da Silva, Ãcaro GusmÃo Pinto Vieira
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- EP ID EP579410
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