Hypoglycemic and Hypolipidemic Effects of Hoya parasiticaVariegata (Apocynaceae) and Crotalaria pallidaAiton (Fabaceae) Leaves in Aloxane-Induced Type 2 Diabetic Rats
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 4
Abstract
Abstract:Traditional plant treatment for diabetes has produced a rising interest now a day. Therefore, the purpose of this study was to determine the hypoglycemic effect and hypolipidemic properties of the methanolic extract of Hoya parasiticaVariegata (Apocynaceae) and ethanolic extract of Crotalaria pallidaAiton (Fabaceae) in alloxan induced diabetic rats. In this study diabetes was induced in rats by intraperitoneal administration of 100 mg/kg of alloxan. Animals were only treated for one week with both the plant extracts at doses of 300 and 600 mg/kg. Metformin (100 mg/kg) was used as standard for comparison. The antidiabetic effect was examined by measuring blood glucose (BG) level at 0, 3, 5 and 7 days after alloxan treatment. Blood samples were collected after 8 days treatment and analyzed for triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) at sacrifice. Both the plants H. parasiticaand C. pallidaat 300 mg/kg and 600 mg/kg showed significant (p<0.05) hypoglycemic effect compared to control and untreated diabetic control rats. Alloxan induced diabetic rats showed moderate to significant increases in the levels of BG, TG, TC, LDL-C while body weight, HDL-C and relative weights of liver and pancreas were decreased to controls (non diabetic rats). Administration of both the plant extracts to alloxan induced diabetic rats resulted in significant decrease in BG, TG, TC and LDL-C and the dose 600 mg/kg of both plant extracts were the most effective. HDL-C levels for both plants were markedly increased after treatment compare to untreated diabetic rats. Results of the treatment study showed that both H. parasiticaand C. pallidaextracts causes antidiabetogenic properties and beneficial effects on diabetic hyperlipidemia. Keywords: Hoya parasitica, Crotalaria pallida, metformin, alloxan, hypoglycemic, hypolipidemic, rat.
Authors and Affiliations
IsratJahan Bulbul
Keywords
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