HYPOGONADISM AMONG HIV INFECTED MALES AND ITS CORRELATION WITH CD4 COUNT
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 34
Abstract
BACKGROUND After introduction of Highly Active Anti-Retroviral Therapy (HAART), the prevalence of hypogonadism among Human Immunodeficiency Virus (HIV) infected males is decreasing. MATERIALS AND METHODS Cross-sectional study was undertaken at ART centre of a medical Institute. The study recruited HIV infected males aged 18 to 65 years receiving ART. Patients with any debilitating chronic illness, diabetes mellitus, chronic smokers or alcoholic, currently on opioids or methadone were excluded. Androgen deficiency in aging male (ADAM) questionnaire was used to screen patients for possible presence of hypogonadism. Patients underwent biochemical evaluation for serum total testosterone (TT), luteinising hormone (LH) and CD4 count. Chi-squared test was used to compare different parameters. Pearson’s correlation coefficient was used to assess any relationship between CD4 count, LH and testosterone. A p-value of <0.05 was considered statistically significant. RESULTS In the study 120 patients were evaluated. The mean age of the patients was 41.61 years. The mean BMI of the patients was 22.47 kg/m2. The mean duration of ART was 6.13 years and mean CD4 count was 442.63 cells/mm3. Hypogonadism was seen in 20 (23.3%) and majority (85.7%) had secondary hypogonadism. There was significant association between hypogonadism and CD4 count but no association was found with body mass index (BMI) and duration of ART. CONCLUSION Hypogonadism is seen in 23.3% of HIV infected males. Majority (85.7%) had secondary hypogonadism. There was significant association of hypogonadism with lower CD4 count.
Authors and Affiliations
Salam Ranabir, Pongener Nungsangla, Mayengbam Premita, Shaini L. , Biplab Singh N. , Bhagyabati Devi S. , Ningshen Robinson
Keywords
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- EP ID EP571103
- DOI 10.18410/jebmh/2018/517
- Views 76
- Downloads 0
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