HYPOLIPIDEMIC POTENTIAL OF RAW SEEDS OF DACRYODES EDULIS ON WISTAR RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 6
Abstract
The phytochemical screening of ethanol extract of Dacryodes edulis seeds and its effect on lipid profile of albino Wistar rats was investigated. Fresh seeds were obtained, air-dried at room temperature and pulverized. The powder was macerated in 80% ethanol and the filtrate was concentrated to obtain crude extract. The crude extract was subjected to phytochemical screening and also administered to albino Wistar rats. Twenty-four (24) albino Wistar rats weighing between 150 – 180g were obtained and randomly selected into 4 groups with 6 animals in each group. Group I served as control while Groups II, III and IV served as test groups and were administered 100, 200 and 300 mg/kg body weight of the extract respectively, daily for 14 days by use of cannula attached to a syringe. All the animals were allowed access to rat feed and clean water ad libitum. Result show that the seed extract has a wide array of phytochemicals which include saponins, flavonoids, terpenes, alkaloids, tannins, cardiac glycosides and phlobatannins. Triglyceride, total cholesterol, LDL-cholesterol and VLDL-cholesterol concentrations were significantly reduced following the administration of the extract to Wistar rats while a dose dependent increase was observed in HDL-cholesterol concentrations. The ethanol extract of seeds of Dacryodes edulis is rich in phytochemicals and have a positive lipid modulatory effects.
Authors and Affiliations
Jessie Idongesit Ndem
Keywords
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