Hypothyroidism as a sequelae following treatment of head and neck cancer
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 1
Abstract
Background: Hypothyroidism is one of the late side effects seen after curative radiotherapy in the head and neck region encompassing part or whole of the thyroid gland. Still thyroid function tests are not a part of routine follow up of head – neck cancer patients treated with radiotherapy with or without surgery and / or chemotherapy. Aim of this study was to to find out the incidence of hypothyroidism in head – neck cancer patients treated with radiotherapy with or without chemotherapy and influence of concomitant chemotherapy. Materials and Methods: Of the 112 patients, 57 (50.8%) were planned to receive radiotherapy alone, 42 (37.5%) to receive neo-adjuvant chemotherapy with Cisplatin and 5-FU and the rest 13 (11.6%) patients to receive concurrent chemo-radiation. Thyroid function tests were done at the beginning of treatment, at six weeks after completion of radiotherapy and thereafter at six weeks’ interval for two years. Results: After 24 months follow up, overall incidence of clinical hypothyroidism of our reported patients was 31.03% and of sub-clinical hypothyroidism was 37.93%. Conclusion: As a significant number of patients develop hypothyroidism following radiotherapy to the neck, thyroid function tests should be included in the routine follow up protocol of such patients.
Authors and Affiliations
S Suresh
Keywords
Related Articles
- EP ID EP496814
- DOI -
- Views 78
- Downloads 0
Absence of Musculocutaneous Nerve Along With Accessory Head of Biceps Brachii.
Musculocutaneous nerve is one of the terminal branches of lateral cord of brachial plexus. This nerve is responsible for innervation of flexor compartment of arm and for cutaneous innervation on lateral surface of forear...
A Study of Anaemia in Pregnancy and Associated Factors at Rural Area
Background: Nutritional anaemia is a world-wide problem with the highest prevalence in developing countries. It’s also one of the most commonly encountered medical disorders during pregnancy contributing significantly to...
Retrospective Study of Various Maternal Factors Responsible For Meconium Stained Amniotic Fluid and Its Impact on Perinatal Outcome
Meconium is derived from the Greek word “meconium-arion”1, meaning “opium-like”. Many maternal factors contribute to passage of meconium before birth which includes maternal age, prolonged gestation, anaemia, hypertensio...
Comparative Study of Serum Calcium, Magnesium and Zinc Levels in Preeclampsia and Normal Pregnancy
The study of serum calcium, magnesium and zinc in preeclampsia proposes the value these biomarkers as indicators in the etiopathogenesis and accessing severity of preeclampsia. Serum levels of calcium, magnesium and zinc...
The Rheological Profile of Cereal Flour Composites as affected by Gamma Irradiation
Retrogradation of starch occurs when the amylose in starch-containing products returns to a less soluble, crystalline state over time. Irradiation has been shown to be a useful method for producing modified starch since...