Imaging Evaluation of Enhancement Patterns of Flat Gall Bladder Wall Thickening and Its Correlation with Clinical and Histopathological Findings
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 4
Abstract
Introduction: Gall bladder Wall Thickening (GWT) is caused by wide spectrum of diseases. Initially Ultrasound (USG) was used as imaging modality for screening of acute abdomen because of its high sensitivity and real time character. Now, Computed Tomography (CT) is used because of its high temporal and spatial resolution. Aim: Evaluation of GWT and its enhancement patterns on contrast enhanced CT scan in a bid to differentiate benign from malignant causes and to correlate the imaging features with clinical and histopathological findings. Materials and Methods: It was a hospital based prospective study in which USG was done as an initial modality for screening and Multi Detector Computed Tomography (MDCT) scan was done later on for detailed evaluation of enhancement patterns of GWT. The study cases were then divided into five CT patterns according to enhancement patterns. The diagnostic performance of MDCT was compared with histopathological and serological findings. Relevant history, clinical examination and routine investigations were done. Results: The one layered pattern with a heterogeneously enhancing thick layered pattern (Type 1) was significantly associated with gall bladder cancer (p<0.001). The sensitivity and specificity of Type 1 enhancement pattern on CT for predicting the Gall Bladder (GB) malignancy were 90.476% and 97.43% respectively. The positive and negative predictive values were 95% and 95%, respectively. Focal wall thickening, irregular margin character and hepatic infiltration by GWT and lymphadenopathy were other findings that predict malignancy (p-value<0.05). Conclusion: MDCT enhancement patterns of a thickened GB wall and associated findings were helpful in differentiating malignant GWT from benign GWT.
Authors and Affiliations
Manoj Mathur, Jasvir Singh, Devinder Pal Singh, Navneet Kaur, Saryu Gupta, Samrin Haq
Keywords
Related Articles
- EP ID EP338645
- DOI 10.7860/JCDR/2017/25472.9624
- Views 120
- Downloads 0
Meckel’s Diverticulum Enterolith: An Extremely Rare Cause of Intestinal Obstruction
Meckel’s diverticulum is usually asymptomatic but occasionally presents with complications. Formation of an enterolith inside a Meckel’s diverticulum is very uncommon and dislodgement of such a stone causing obstruction...
Histopathological Analysis of Psoriasis in a Study of 24 Cases
ABSTRACT Introduction: As for any other organ system, diagnosis of skin disease involves history and examination. An instant diagnosis can be arrived upon by virtue of visibility of the skin taking into account various v...
High Yield Expression and Modified Purification of Novel Recombinant Truncated Protein FimH.MrpH against Urinary Tract Infections by Escherichia coli and Proteus mirabilis
ABSTRACT Introduction: Urinary Tract Infections (UTIs) rank third among the list of most common bacterial infections. FimH and MrpH are the most important antigens of Escherichia coli and Proteus mirabilis isolates, resp...
Photogrammetric Correlation of Face with Frontal Radiographs and Direct Measurements
Introduction: Photogrammetry is a science of making measurements from photographs. As cephalometric analysis till date has focused mainly on skeletal relationships, photogrammetry may provide a means to reliably assess a...
Functional Recovery after Stroke: Role of Irrational Beliefs
ABSTRACT Introduction: Stroke is a disabling condition that affects the physical as well as cognitive areas of functioning. Recovery from a stroke can be interrupted by many factors including psychological. Our beliefs p...