Immune Checkpoint Inhibitors and Myocarditis
Journal Title: BMH Medical Journal - Year 2019, Vol 6, Issue 3
Abstract
Immune checkpoint inhibitors (ICI) are a promising group of novel anti cancer drugs. They are monoclonal antibodies targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed cell death 1 (PD-1) and its ligand (PD-L1). This group of drugs have been useful in a wide variety of malignancies with an otherwise poor prognosis. Important drugs in this class are ipilimumab, nivolumab, pembrolizumab and atezolizumab. Though they are excellent therapeutic options in several malignancies, some immune-related adverse effects have been noted, of which autoimmune myocarditis is potentially life threatening. Pathology of ICI‐associated myocarditis is characterized by intense infiltration by T lymphocytes and macrophages. Severe myocarditis will mandate suspension of ICI treatment and initiation of high dose corticosteroids (prednisolone or methylprednisolone).
Authors and Affiliations
Johnson Francis, Jame Abraham
Keywords
Related Articles
- EP ID EP647786
- DOI -
- Views 121
- Downloads 0
Current Thinking In Pediatric Peri-operative Fluid Therapy
Proper perioperative fluid management is critical to maintain cardiovascular stability and adequate tissue perfusion. The volume and composition of fluid should be adapting to the physiology of the child and compensating...
Autoimmune Encephalitis : A Case Report
Background: The etiology of encephalitis are numerous and extensive investigations for infectious agents and other causes are often negative. Case characteristics: Five year old girl presented with abnormal / aggressive...
Blood Hyperviscosity Syndrome Revealing Multiple Myeloma in Emergency Department: Report of a New Case
Introduction: Blood hyperviscosity syndrome is a rare and serious complication of multiple myeloma. It is an unusual mode of presentation of multiple myeloma. Case presentation: A 60-year-old man admitted to the emergen...
A Rare Tumour With A Rare Presentation
Sarcomatoid variant of urothelial carcinoma is a very rare tumor, and this tumour arising in a ureteric location is even rarer still. We report a case of such a tumor with this rare presentation.
Persistent Trigeminal Artery
Trigeminal artery is the commonest of the four primitive anastomoses between the carotid and vertebrobasilar system that may rarely persist in adults, with an angiographic incidence of 0.1 - 0.6%. We present the CT and M...