Immunogenicity of Hydrolysate Formulas in Children (Part 1). Review of 202 Reactions
Journal Title: Journal of Vaccines and Immunology - Year 2015, Vol 1, Issue 1
Abstract
Cow's milk (CM) protein hydrolyzed formulas (HFs) appeared in the 40's with the aim of decreasing or eliminating the allergenicity of CM proteins, and in addition of reducing the risk of sensitization. In recent years the so-called “hypoallergenic” (HA) formulas have been developed. The use of such HFs is based on the premise that predigested proteins, when fed as amino acids and peptides, provide nutrients in a not antigenic form. Thus, protein HFs have been classified as HA. These formulas are processed by heat and enzymatic hydrolysis, and the conformational and sequential structures are more or less changed. The formulas contain peptides of lower molecular weight (MW) than the native protein source, which are thought to be less immunogenic. HFs appear to be nutritionally adequate and infants generally gain weight until they refuse the formula because of its bad taste. However, caution should be taken when such formulas are given for prolonged periods since no data is available on nutritional assessment of infants exclusively fed HFs for several months. In this paper we report and discuss > 202 reactions to different HFs, including cases of anaphylactic shock and of apparent life-threatening events.
Authors and Affiliations
Cantani Arnaldo
Keywords
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- EP ID EP553523
- DOI 10.17352/jvi.000005
- Views 68
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