IMMUNOHAEMATOLOGICAL PROFILE OF MATERNAL ANTIBODY-MEDIATED ABO HAEMOLYTIC DISEASE OF FOETUS AND NEWBORN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 72
Abstract
BACKGROUND The potency of anti-A and anti-B was determined by racial and environmental factors. With respect to ethnic groups, the prevalence and intensity of maternal-newborn ABO incompatibility varied in different populations. The aim of this study is to describe the immunological profile of ABO HDFN. Settings and Design- This was a descriptive study conducted in neonates with ABO HDFN. Research was conducted in Depts. of Transfusion Medicine and Neonatology division of Paediatrics in Govt. Medical College, Trivandrum. MATERIALS AND METHODS Those neonates who fulfilled the inclusion criteria were enrolled in this study. Demographic details, maternal details, bilirubin and haemoglobin levels were recorded. Investigations such as maternal blood grouping and antibody titration were done. In infant’s blood sample direct antiglobulin test, blood grouping and elution was performed. Statistical Analysis- All statistical data were analysed using SPSS software version 16. RESULTS Among mothers of infants with ABO HDFN 25 (22.7%) had a titre of 128, 34 (30.9%) had 256, 35 (31.8%) had 512 and 16 (14.6%) had 1024. Among 110 infants 34 (30.9%) were DAT positive, while the rest 76 (69.1%) were DAT negative. While DAT positive was graded 13 (11.8%) fell in grade 1, 16 (14.6%) in grade 2, 3 (2.7%) in grade 3 and 2 (1.8%) in grade 4 categories. Eluate from 59 (53.6%) of infants with ABO HDFN gave a positive result, while the rest 51 (46.4%) gave a negative result. Out of that 59 (53.6%) elution positive infants, 34 (30.9%) had a positive DAT and 25 (22.7%) had a negative DAT; 51 (46.4%) of infants were negative for both elution and DAT. CONCLUSION Mothers of infants with ABO HDFN had an antibody titre of 128 - 1024. Almost one-third of infants were DAT positive and majority fell in grade 1 or 2. Eluate from half of infants gave a positive result.
Authors and Affiliations
Sajith Vilambil, Meena Dharmadas, Kumari Krishnakumariamma Chakrapani Usha, Shaiji Panthiyil Shahulhameed, Chitra James, Anjaly Padmavilas Sasikala, Soonam John, Vineeth Rajgopal
Keywords
Related Articles
- EP ID EP265554
- DOI 10.14260/jemds/2017/1110
- Views 100
- Downloads 0
A DESCRIPTIVE STUDY ON THE CLINICAL MANIFESTATIONS AND SEVERITY OF PSORIASIS IN PATIENTS PRESENTING TO DERMATOLOGY OPD OF A TERTIARY HEALTH CARE CENTER IN CENTRAL KERALA
BACKGROUND Psoriasis is heterogeneous in its history, manifestations, presenting age, sites affected and environmental triggers. It presents as small localized lesions to generalized exfoliation type. An understanding of...
A STUDY OF PAIN AND DEPRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS
BACKGROUND Rheumatoid arthritis is a psychosomatic illness, in which psychological factors play a major role in disease process. Comorbid depression and physical pain are major contributing factors (Chandarna et al, 1 Co...
DETECTION OF AMPC BETA LACTAMASES IN CEFOXITIN-RESISTANT GRAM-NEGATIVE CLINICAL ISOLATES USING PHENYLBORONIC ACID
BACKGROUND AmpC β-lactamases are Ambler class C enzymes that confer resistance to extended spectrum cephalosporins and are not inhibited by β-lactamase inhibitors. These enzyme-producing organisms produce infections that...
ANATOMICAL AND FUNCTIONAL OUTCOME OF COMMINUTED INTRA-ARTICULAR DISTAL RADIAL FRACTURES TREATED WITH VOLAR BUTTRESS PLATING AND ANTI-IMPACTION KIRSCHNER WIRE THROUGH THE RADIAL STYLOID
BACKGROUND Comminuted Colles’ fracture is common after accident and fall from height. Residual deformity after treatment adversely affect wrist motion and hand function.(1) Collapse on metaphysis and radial styloid with...
HORSESHOE KIDNEY WITH ACCESSORY RENAL ARTERY AND EXTRARENAL CALYCEAL SYSTEM – A CASE REPORT
The congenital anomalies of kidney are important as they may cause renal failure in middle age group. The horseshoe kidney is the most common congenital fusion anomaly in which both kidneys were fused at their...