Immunohistochemical expression of MUC1 in different grades of oral squamous cell carcinoma
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 2
Abstract
Background: MUC1 mucin is a membrane-bound mucin encoded by the MUC1 gene. Alteration in glycosylation of mucins is associated with the development and progression of malignancy. Therefore, mucins are used as markers which are valuable to distinguish normal and diseased conditions. Although expression of MUC1 has been identified in a various neoplasms, only few studies have done to estimate MUC1 expression in oral carcinomas. Aims and Objectives: The aim of this study is to evaluate, compare, and correlate the MUC-1 immunoexpression and its significance in normal oral mucosa (NOM) and in different grades of oral squamous cell carcinoma (OSCC). Materials and Methods: Our study included 30 histopathologically diagnosed tissue sections of different grades of OSCC, which were immunostained for MUC1 mucin expression and 10 cases of NOM as controls. The percentage of the positivity of cells and staining intensity was analyzed according to the immunoreactive scoring system and statistically analyzed by Pearson’s Chi-Square test. Membranous and cytoplasmic staining was considered as positive for MUC1 mucin immunoexpression. Results: There was statistically significant difference in the percentage of positivity of cells and staining intensity from NOM to OSCC and also in different grades of OSCC with a P < 0.001. Conclusion: The findings of our study suggest that MUC 1 plays an important role in pathogenesis and can be regarded as a valuable marker for OSCC.
Authors and Affiliations
Kandikatla Carmel Shobita
Keywords
Related Articles
- EP ID EP525331
- DOI 10.21276/apjhs.2018.5.2.31
- Views 173
- Downloads 0
A profile of poisoning cases attending to Pondicherry Institute of Medical Sciences, Puducherry
Introduction: Poisons are regarded as the silent weapons which can be easily used without arousing suspicion and without violence. Over the counter availability of poisons, knowledge regarding the fatality of poisons amo...
Examination of the relationship between physical activity levels and healthy lifestyle behaviors of university students
Objectives: This study was conducted to determine and correlate physical activity levels and healthy lifestyle behaviors of university students. Materials and Methods: The sample of the research consisted of 155 students...
A clinical study on role of surgical management of clavicle fractures in adults
Clavicle, the horizontal bone of the body fractures is seen commonly in Road traffic accidents, fall from heights and also in simple falls. The clavicle fractures account for about 5-10% of all fractures. Traditionally i...
Placental thickness estimation by ultrasonography and its correlation with gestational age in normal pregnancies in late 2nd and 3rd trimester
Introduction: At present, the most effective way to date pregnancy is by the use of ultrasound. Placental thickness can be used as a new parameter to estimate gestational age. Aim: The aim is to study placental thickness...
A clinical study of etiological factors contributing to third, fourth and sixth cranial nerve palsies
Aim: To determine etiological factors contributing to third, fourth and sixth cranial nerve palsies. Objectives: To know the distribution of nerve palsies according to age. To determine distribution patterns of various e...