IMMUNOMODULATORY EFFECTS OF TINOSPORA CORDIFOLIA LOTION ON INTERLEUKIN-1, INTERLEUKIN-6 AND INTERLEUKIN-8 LEVELS IN SCABIES-INFECTED PEDIATRIC PATIENTS: A SINGLE BLIND, RANDOMIZED TRIAL
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2014, Vol 6, Issue 3
Abstract
Scabies is a contagious, parasitic skin infestation caused by Sarcoptes scabiei mite, which has the ability to regulate the host’s inflammatory and immune responses. It is a serious community health problem in many less-developed countries. A randomized, controlled, parallel, pilot clinical study was performed to investigate the immunomodulatory effect of the formulated Tinospora lotion in clinically diagnosed scabies-infected patients through Enzyme-Linked Immunosorbent Assay (ELISA) for Interleukin-1, Interleukin-6 and Interleukin-8 using blood serum samples. The pediatric patients were treated with Tinospora and Permethrin lotions for three consecutive days for two weeks. Blood extraction was performed before and after the second and fourth week of treatment period. Tinospora lotion significantly reduced the Interleukin-1 (IL-1) and Interleukin-6 (IL-6) levels from Day 14 to Day 28 (p=0.0002) comparable to Permethrin lotion (p<0.050). Permethrin efficiently decreased Interleukin-8 (IL-8) levels than Tinospora at Day 14 (p=0.0155). Down regulation of Interleukin 1, 6, and 8 levels in scabies infestation inhibits hyperkeratosis and infiltration of inflammatory cells into scabietic lesion. The modulation effect of the Tinospora lotion on interleukin levels reinforces its anti-scabies activity.
Authors and Affiliations
AL Castillo, JDA Ramos, JL De Francia, PF Quilala, MU Dujunco
Keywords
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