IMMUNOPROPHYLAXIS OF PSEUDOMONOSIS: ACHIEVEMENTS AND PERSPECTIVES
Journal Title: Annals of Mechnikov Institute - Year 2018, Vol 0, Issue 2
Abstract
The review article presents a retrospective analysis of attempts to develop effective vaccines for pseudomonas prophylaxis. P. aeruginosa vaccine has been sought for 40 years; however it is still not available. The increased understanding of P. aeruginosa pathogenesis and its virulence factors supported the recognition of potential immunogens and passive immunotherapy that could be used for the development of an effective vaccine. These immunogens are situated in structural components such as lipolysaccharides, pili, flagella, outer membrane proteins or are part of secreted products such as proteases, exotoxins and mucoid exopolysaccharides. There have been significant advances in later years; nonetheless there is clear need for additional basic research to further increase the understanding of those elements of immune response to P. aeruginosa.
Authors and Affiliations
N. I. , Gorodnitskaya, L. N. , Gabysheva, S. A. , Derkach, A. V. Martynov
Keywords
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- EP ID EP612788
- DOI 10.5281/zenodo.1303954
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