Impact of BCG Vaccination Status on Sputum Conversion Rate in New Sputum Positive cases of Pulmonary Tuberculosis
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Objectives: Sputum conversion rates (SCR) at the end of intensive phase of treatment of pulmonary tuberculosis varies and knowledge of factors involved is, inadequate. It has been reported that presence of a BCG scar was associated with greater rate of sputum conversion at the end of intensive phase (IP) of treatment. Hence, this study was undertaken with aim of studying the relationship between BCG vaccination status and sputum conversion rate in pulmonary tuberculosis (PTB) patients. Materials And Methods: This was a hospital based observational study done at Assam Medical College and Hospital, Dibrugarh from July 2012 to June 2013. All new sputum smear positive (SSP-PTB) patients were put on antitubercular therapy under DOTS and followed up with repeat sputum microscopy at the end of intensive phase. A comparative study on the outcome was done between BCG scar positive and negative cases and statistical analysis done. Results: All the 102 new SSP-PTB cases successfully completed intensive phase treatment under DOTS. Out of these 19 patients had to be put on extended IP of 1 month. BCG scar was present in 64.17% cases and absent in 35.29%. Overall, 81.37% of new sputum positive (NSP) cases converted at the end of second month IP on DOTS. In BCG scar present group, sputum conversion rate (SCR) was 90.90% whereas in scar absent group it was 63.89%, showing a significant ‘p’ value of 0.0013.In the extended IP group 94.48% cases with scar converted, while 22.22% without BCG scar remained non-converted with a significant ‘p’ value of 0.0009. Conclusion: New SSP-PTB patients with evidence of previous BCG vaccination, show a significantly better sputum conversion rate at the end of intensive phase of DOTS
Authors and Affiliations
Priyam Goswami
Keywords
Related Articles
- EP ID EP214104
- DOI -
- Views 57
- Downloads 0
Epidemiological Study of Opportunistic Infections in HIV Sero Positive Patients in South India
Introduction: Human Immunodeficiency Virus leads (HIV) to Acquired Immune Deficiency Syndrome(AIDS) and opportunistic infections (OI’s) and causes increased morbidity and mortality of such patients which considerable aff...
Intravenous Dexmedetomidine in Attenuating Intubation Response in Awake Fibreoptic Nasal Intubation
Introduction: Fibreoptic intubation is a is an effective, safe and reliable technique for difficult airway management. Optimal intubating conditions and patient comfort are paramount while preparing the patient for fibre...
Role of Glucosamine Sulphate Supplements on Intra Ocular Pressure Given in Osteoarthritis Treatment– A Case Series
Aim: To analyze role of Glucosamine sulphate supplements given for treatment of Osteoarthritis on intraocular pressure. Materials & Methods: A case series of 100 patients who were diagnosed to have Osteoarthritis were se...
Study to Determine Relapse and Mortality Rates in Tuberculosis Cases and their Epidemiological Correlates: A Historical Cohort Study
Background: India is the country with the highest burden of TB. The World Health Organization (WHO) statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of...
Effects of Premedication with Dexmedetomidine on Perioperative Hemodynamics and Anesthetic Requirements during Elective General Abdominal Surgeries
Background and Aims: Effective use of sedative-hypnotic and analgesic agents is an integral part of providing patient comfort and safety for patients during general anaesthesia. The present study was carried out to evalu...