Impact of BCG Vaccination Status on Sputum Conversion Rate in New Sputum Positive cases of Pulmonary Tuberculosis
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Objectives: Sputum conversion rates (SCR) at the end of intensive phase of treatment of pulmonary tuberculosis varies and knowledge of factors involved is, inadequate. It has been reported that presence of a BCG scar was associated with greater rate of sputum conversion at the end of intensive phase (IP) of treatment. Hence, this study was undertaken with aim of studying the relationship between BCG vaccination status and sputum conversion rate in pulmonary tuberculosis (PTB) patients. Materials And Methods: This was a hospital based observational study done at Assam Medical College and Hospital, Dibrugarh from July 2012 to June 2013. All new sputum smear positive (SSP-PTB) patients were put on antitubercular therapy under DOTS and followed up with repeat sputum microscopy at the end of intensive phase. A comparative study on the outcome was done between BCG scar positive and negative cases and statistical analysis done. Results: All the 102 new SSP-PTB cases successfully completed intensive phase treatment under DOTS. Out of these 19 patients had to be put on extended IP of 1 month. BCG scar was present in 64.17% cases and absent in 35.29%. Overall, 81.37% of new sputum positive (NSP) cases converted at the end of second month IP on DOTS. In BCG scar present group, sputum conversion rate (SCR) was 90.90% whereas in scar absent group it was 63.89%, showing a significant ‘p’ value of 0.0013.In the extended IP group 94.48% cases with scar converted, while 22.22% without BCG scar remained non-converted with a significant ‘p’ value of 0.0009. Conclusion: New SSP-PTB patients with evidence of previous BCG vaccination, show a significantly better sputum conversion rate at the end of intensive phase of DOTS
Authors and Affiliations
Priyam Goswami
Keywords
Related Articles
- EP ID EP214104
- DOI -
- Views 71
- Downloads 0
The Pattern of Microbial Keratitis in soft Contact Lens Wearers in a Tertiary Care Hospital in Eastern India
Background: Soft contact lenses are increasing in trend since a decade and are being used for both cosmetic and therapeutic purposes. Lack of compliance and poor hygiene towards lens care is one of the main causes associ...
Long Term Outcome after Concurrent Chemo radiation with Cisplatin in Carcinoma Cervix
Aim: The aims of this study were to examine treatment outcomes (survival, local control and toxicity) in patients with cervical cancer treated with chemoradiation in stage 1B2-1VA carcinoma of cervix in Department of Rad...
Tracheal Reconstruction Using Pericardium in Emergency as a Life Saving Procedure in Cases of Severe Tracheal Stenosis
Background: Post intubation tracheal stenosis followed by tracheostomy resulting in destruction of long segment of trachea remains a serious clinical problem. In this study we review our experience with technique of trac...
Morbidity Pattern of Non-Communicable Diseases among Pregnant Women Attending A Tertiary Care Hospital in Kashmir Valley, India
Background: The study was conducted with the aim to observe the pattern of non-communicable diseases, mainly hypertension, diabetes mellitus, hypothyroidism and anemia in antenatal cases who attended outpatient departmen...
To Study the Prevalence of Non Alcoholic Fatty Liver Disease among Overweight and Obese Persons Undergoing Preventive Health Checkups in a Tertiary Care Hospital
Introduction: Raised Body Mass Index (BMI) is on an increasing trend nowadays, associated with various complications. The present study was planned to determine the prevalence of Non Alcoholic Fatty Liver Disease (NAFLD)...