Impact of Calcium-Vitamin D Combination Tablets on the Dissolution Pattern of Four Different Brands of Rosuvastatin Calcium Tablets: An UV Analysis
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 3
Abstract
This study was designed to find out the impact of calcium-vitamin-D combination tablets on the dissolution profile of rosuvastatin calcium tablets. For this purpose one of the highly prescribed brands of calcium-vitamin D supplement was chosen along with four different brands of rosuvastatin calcium tablets. The experiments were carried out using USP apparatus II and UV spectroscopy. Initially the dissolution pattern for each of the four rosuvastatin calcium brands was observed individually. After that these were co-administered with the calcium-vitamin D supplement tablets to see if there is any change in their dissolution pattern. A significant decline in the dissolution rate was observed in all the co-administered experiments. In case of brand A, B and C the dissolution rate decreased to around 20%. At the same time, this drop in dissolution was the lowest for Brand D which was approximately 10%. The probable reason behind this decreased dissolution may be due to the common ion effect. This study therefore suggests not to take calcium-vitamin D supplement along with the rosuvastatin calcium tablets at the same time. There should be sufficient gap between their intakes.
Authors and Affiliations
Md. Anisur Rahman
Keywords
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