Impact of Calcium-Vitamin D Combination Tablets on the Dissolution Pattern of Four Different Brands of Rosuvastatin Calcium Tablets: An UV Analysis
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 3
Abstract
This study was designed to find out the impact of calcium-vitamin-D combination tablets on the dissolution profile of rosuvastatin calcium tablets. For this purpose one of the highly prescribed brands of calcium-vitamin D supplement was chosen along with four different brands of rosuvastatin calcium tablets. The experiments were carried out using USP apparatus II and UV spectroscopy. Initially the dissolution pattern for each of the four rosuvastatin calcium brands was observed individually. After that these were co-administered with the calcium-vitamin D supplement tablets to see if there is any change in their dissolution pattern. A significant decline in the dissolution rate was observed in all the co-administered experiments. In case of brand A, B and C the dissolution rate decreased to around 20%. At the same time, this drop in dissolution was the lowest for Brand D which was approximately 10%. The probable reason behind this decreased dissolution may be due to the common ion effect. This study therefore suggests not to take calcium-vitamin D supplement along with the rosuvastatin calcium tablets at the same time. There should be sufficient gap between their intakes.
Authors and Affiliations
Md. Anisur Rahman
Keywords
Related Articles
- EP ID EP493834
- DOI -
- Views 120
- Downloads 0
A Study of the Risk Factors of Hepatitis B among Adult Rural Population of Maner Block, Patna
Background: Communicable diseases remain a significant public health problem despite the progress in diagnosis, treatment, and prevention, the wide spread use of antibiotics and vaccination. Now a days, sexually transmit...
Role of frontal sinus in gender determination and personal identification using PA view of skull - A digital radiographic study
Introduction: identification of a person is very important after an unfortunate natural calamity or criminal cases. If the body is decomposed and only skeletal fragments are available, identity of an individual is retrie...
Internal Fixations of Mandibular Angle Fracture
This study was done to review various internal fixation methods for the treatment of Mandibular angle fractures. It reviewed: 1) the epidemiology, 2) the aetiology, 3) the cross-section area of the angle along with prese...
A Study on Congenital Malformations in Fetuses of Mothers with Consanguineous Marriages Mallela Padmavathi.
Aims and Objectives Assess the association of the congenital malformations with consanguinity of the parents &correlate the association of consanguinity with the occurance of congenital malformations, Materials and Meth...
Wavelet Based Seizure Detection using Scalp EEG
Epilepsy, the most common neurological disorder characterized by sudden and recurrent neuronal firing in the brain can be detected by analyzing electro-encephalogram of the subject. EEG signal processing consists of thre...