IMPACT OF EXERCISE ON ENDOTHELIUM-DEPENDENT VASODILATOR SERUM NITRIC OXIDE
Journal Title: International Journal of Basic and Applied Physiology - Year 2018, Vol 7, Issue 1
Abstract
The vascular endothelium produces a large number of vasodilator and vasoconstrictor compounds which regulate vascular tone. Nitric Oxide (NO) is recognised to be the most important and best characterised mediator; its intrinsic vasodilator function is commonly used as a surrogate index of endothelial function. Various studies have demonstrated that exercise training improves endothelium-dependent vasodilator function. Yoga is a group of physical, mental, and spiritual practices or disciplines which originated in ancient India. The poses and stretches are thought to have physical and mental health benefits. Optimum exercise training schedules in the form of Yogasanas & pranayam may result in possible sequential changes in the endovascular milieu. Yoga exercise mediated improvement in endothelial function may provides plausible cardio protective benefits of exercise training. We evaluated the impact of exercise in the form of yoga v/s sedentary life on serum Nitric Oxide (NO). This prospective study consisted of 70 volunteer subjects in the age range of 18 to 73 years, mean age 33 yrs, from a small locality in the north of Bangalore. Serum Nitric Oxide levels was measured using Cadmium reduction method. The subject’s history of regular exercise, type & duration of exercise was evaluated; those who did not perform regular exercise of at least 2 days a week were classified as sedentary. 40 subjects who performed regular exercise in the form of Yoga and 30 subjects who did not perform regular exercises were classified as sedentary. Sedentary group was significantly younger with a mean age of 18.5 yrs compared to the exercise group whose mean age was 44yrs. 22% of the subjects in the exercise group had some coexisting disease with 70% requiring medication, compared to no coexisting disease in sedentary group who were much younger. BMI & Waist Hip ratio was significantly higher in exercise group. The exercise group had been performing Yoga for a mean duration of 3.64±5.40 years. Comparison of subject who practiced yoga for and those who were sedentary revealed a stastically significant higher serum Nitric Oxide. Serum Nitric Oxide (NO μmol/l) was 77.26±37.71 in those who performed regular yoga exercise compared to 23.57±5.83 in Sedentary subjects <0.001**. It also showed a significant correlation with age. Hence our observation in this study was even though Subjects in the exercise group was were two Decades older with higher BMI and FBS and Co-morbidities the serum Nitric Oxide levels were comparatively higher compared to younger sedentary subjects. The presence of significantly higher levels of Nitric Oxide NO can be attributed to the continued regular exercise in the form of Yoga practices.
Authors and Affiliations
Preeti Bangalore Laxmangowda, Elizabeth joseph, Wilma Delphine Silvia, K. P. suresh
Keywords
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