Impact of laparoscopic ovarian drilling on anti-mullerian hormone levels in women with clomiphene resistant polycystic ovary syndrome
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Patients with PCOS not only have raised androgen levels which leads to anovulation but may also have high AMH levels. When ovulation induction fails, androgen levels are reduced by laparoscopic ovarian drilling (LOD) thereby effecting ovulation and thus improving fertility. Studies have suggested that LOD also reduces AMH levels and the degree of its fall may forecast the success of LOD. Materials and Method: The study objective was to evaluate baseline AMH levels and its change post LOD in patients with clomiphene resistant infertility, and correlate with spontaneous rates of ovulation and pregnancy. Results: AMH levels were found to be high in clomiphene resistant PCOS. LOD was found to be safe and effective in the management of these patients and it caused statistically significant drop in AMH levels effecting spontaneous ovulations and pregnancies. Though the degree of fall did not correlate statistically with the success of the procedure, the chances of pregnancy were found to better in patients whose pre-LOD AMH levels were higher. Conclusion: AMH levels could be a useful marker in PCOS related infertility with clomiphene resistance and LOD could be a safe and effective option for management of patients with high AMH levels and fall in AMH levels may emerge as a prognostic indicator. Randomized studies with adequate sample size would bring out the utility AMH as a prognostic marker in PCOS related infertility.
Authors and Affiliations
Monica Saraswat, Tony Jose, Meenakshi Rajput, Nilopher Siddique
Keywords
Related Articles
- EP ID EP314960
- DOI 10.18231/2394-2754.2017.0066
- Views 85
- Downloads 0
Impact of gestational diabetes mellitus on maternal & fetal outcome
Background: Women with GDM are at increased risk for adverse obstetric and perinatal outcome. Hence, it is imperative that an early detection and management of the disease is done to ensure better maternal and fetal outc...
Obstetric hysterectomy – An analysis
Objectives To study the etiological factors maternal morbidity and mortality in patients who underwent obstetric hysterectomy at our tertiary care centre during the period from April 2014 September 2016Study Design It i...
Rare case of Rupture Bicornuate Uterus
Introduction: Uterine rupture in pregnancy is a rare and often complicate with a high incidence of fetal and maternal morbidity. Bicornuate uterus is a rare uterine anomaly result from incomplete fusion of the two Muller...
Abnormal uterine bleeding: A study of its clinical spectrum and incidence of histopathological patterns of endometrium as a function of age with parity
Introduction Abnormal uterine bleeding AUB is a common complaint affecting majority of pre and postmenopausal women Endometirum is a dynamic tissue and is affected by a wide range of histopathological lesions The causes...
Management of missing threads of IUCD
Introduction: Intra uterine contraceptive device is an effective, reversible and long term method of contraception. The device is made of poly ethylene which is impregnated with barium sulphate to render it radio opaque...