Implication of Tumor Necrosis Factor - Alpha in Preeclampsia
Journal Title: Applied Medical Informatics - Year 2008, Vol 23, Issue 3
Abstract
[i][b]Introduction[/b][/i]: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy. [i][b]Aim[/b][/i]: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of preeclampsia. [i][b]Material and Method[/b][/i]: A transversal study was performed in three groups of patients: non-pregnant patients, patients with normal pregnancies in the third trimester, patients with preeclampsia. Serum TNF-α levels were determined using the immunometric sandwich EIA method. [i][b]Results[/b][/i]: The results obtained confirm a significant increase (p<0.01) in circulating TNF-α levels in the last trimester of pregnancy, compared to the non-pregnant status. Significantly increased serum TNF-α concentrations (p<0.001) were also found in pregnant patients with preeclampsia, compared to normotensive pregnant women. [i][b]Conclusion[/b][/i]: This proinflammatory cytokine can be a potential marker of the severity of the preeclamptic syndrome, without being an indicator of the fetal status at birth.
Authors and Affiliations
Dan Mihu, Nicolae COSTIN, Ligia BLAGA, Septimiu CIUCHINĂ, Raluca POP
Keywords
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