IMPROVEMENT OF GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF BRASSICA RAPA SUBSP. RAPA ROOTS AND ZINGIBER OFFICINALE RHIZOMES
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 7
Abstract
Background. Brassica rapa subsp. rapa (Brassicaceae family) and Zingiber officinale (Zingiberaceae family) are two plants cultivated in Bangladesh, respectively, for consumption as vegetable and as spice. A number of Brassicaceae and Zingiberaceae family plants have previously been reported to have antihyperglycemic properties. It was therefore of interest to determine the antihyperglycemic potential of a polyherbal formulation containing the roots of the first and rhizomes of the second plant. Methods. Oral glucose tolerance test (OGTT) was done to evaluate antihyperglycemic potential. Results. In oral glucose tolerance tests, methanol extract of roots of Brassica rapa subsp. rapa (MEBRR), administered at a dose of 400 mg per kg body weight reduced blood glucose by 30.8%. Methanol extract of rhizomes of Zingiber officinale (MEZO), administered at the same dose reduced blood glucose by 33.6%. Administration of a combination of MEBRR and MEZO (1:1, w/w), tentatively termed MEBRZO, significantly and dose-dependently reduced blood glucose levels in glucose-loaded mice by 32.5, 36.3, 40.4, and 44.5%, respectively, at doses of 50, 100, 200 and 400 mg each per kg body weight in mice. By comparison, a standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels by 46.9% at a dose of 10 mg per kg. Conclusion. MEBRZO can be used as a source for blood glucose lowering in diabetic patients in the absence of antihyperglycemic drugs.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP626634
- DOI -
- Views 155
- Downloads 0
ERUCISM IN FEMALE ADULT BOXER CAUSED BY Cocytius antaeus Drury, 1773 (Lepidoptera, Sphingidae): A CASE IN MEXICO CITY
In this article we present the case of an adult Bóxer bitch that developed ulcerative glosso-palatitis due to exposure to caterpillar of Cocytius antaeus. The insect was recovered. Accidents with caterpillars were descri...
CONCEPT OF POST-STROKE DEPRESSION IN AYURVEDA: A SCIENTIFIC REVIEW
A complex picture is emerging in which the sequence of causality seems to spiral on itself as the medical science is learning more about the interaction between depression and cerebrovascular disease (CVD). Progressive b...
COMPARATIVE STUDY OF VERTICAL MARGINAL FIT ON IMPLANT ABUTMENT USING METAL CERAMIC CROWNS, FULL CONTOUR ZIRCONIA CROWNS (CAD/ CAM) AND VENEERED ZIRCONIA CROWNS (CAD/ CAM) (AN IN VITRO STUDY)
Background: Marginal fitness is an important factor in success and longevity of implant – retained restoration.) Objective: To evaluate and compare vertical marginal fit among three materials used in construction crowns...
EVALUATION OF HEPATOPROTECTIVE EFFECTS OF Setaria megaphylla (STEUD) T. DUR AND SPHINZ (POACEAE) ROOT EXTRACT ON PARACETAMOL-INDUCED INJURY IN RATS.
Background: Setaria megaphylla (Steud) T. Dur and Schinz (Poaceae), is a popular medicinal plant used by the indigenes of Niger Delta Nigeria to treat malaria, hemorrhoids, urethritis, inflammation, diabetes, fevers and...
A COMPREHENSIVE REVIEW ON NOVEL ANTIDIABETIC AND ANTIHYPERTENSIVE DRUGS
Diabetes mellitus is a common form of metabolic disorder where level of blood glucose in the blood stream raises high, because of deficiency of insulin and development of insulin resistance in diabetic individuals. It is...