In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor
Journal Title: International Journal of Pharmaceutical Sciences and Developmental Research - Year 2017, Vol 3, Issue 1
Abstract
Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help explain molecular tool behind its inhibitory action. Molecular relations of tenidap with the catalytic trio (His523, His518, Ile875) inside active or dynamic position of 5-lipoxygenase through hydrogen bonding, appears to the major reason elaborate in its substantial 5-lipoxygenase activity of inhibition.
Authors and Affiliations
Noor Asma
Keywords
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- EP ID EP555627
- DOI 10.17352/ijpsdr.000015
- Views 66
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In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor
Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help explain molecula...