IN-SILICO MOLECULAR DOCKING ANALYSIS OF ISOLATED HOMOISOFLAVANONES FROM BULBS OF LEDABOURIA REVOLUTA AS GABAA RECEPTOR INHIBITORS
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate central nervous system (CNS); it activates the GABAA receptors that play a role in epilepsy. Targeting GABAA receptors through specific enhancement of neuronal inhibition involving GABA can be a better mechanism for identification of novel antiepileptic drugs. In this report, screening of novel isolated homoisoflavanones from bulbs of Ledabouria revoluta against human GABRB3 active site using molecular docking studies. The docking analysis reveals the identification of leads with favorable binding energy and hydrogen bond interactions confirmed the effective modulation of the receptor. Based on the dock score and number of hydrogen bond interactions, compound 3 observed to be the most potent.
Authors and Affiliations
E. Sujatha et al.
Keywords
Related Articles
- EP ID EP627568
- DOI 10.13040/IJPSR.0975-8232.10(9).4315-21
- Views 77
- Downloads 0
STUDIES ON ANTIMICROBIAL ACTIVITY OF ZIZIPHUS RUGOSA LAM. PERICARP
The desire of the present study was to investigate in-vitro antimicrobial activity on different crude extracts of Ziziphus rugosa pericarp. The antibacterial assay was carried out against Bacillus subtilis MTCC 1133, Sta...
IMPLEMENTATION OF FRACTION OF DESIGN SPACE TO ASSESS PREDICTION CAPABILITY OF RESPONSE SURFACE DESIGN TO OPTIMIZE MODIFIED RELEASE TABLETS OF HYDROCHLOROTHIAZIDE
Selecting the best possible design is an uphill task considering a lot of criteria which must be scrutinized while choosing any design out of many alternative design options available. The experimental design is often co...
DEVELOPMENT AND VALIDATION OF A SENSITIVE AND SPECIFIC HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ASSAY OF A BINARY MIXTURE OF PANTOPRAZOLE AND DOMPERIDONE IN ORAL SOLID DOSAGE FORMULATIONS
A simple new rapid, accurate, robust, and specific HPLC method was developed for the assay of pantoprazole and domperidone from the oral solid dosage pharmaceutical formulations. The reverse-phase chromatographic method...
A COMPREHENSIVE REVIEW ON COSTUS PICTUS D. DON
Costus pictus is rhizomatous medicinal herb, commonly known as “Insulin plant,” well known for its therapeutic properties. Many important and beneficial aspects of C. pictus are reported, which includes anti-diabetic, an...
IMPACT OF PETROCHEMICAL EFFLUENT ON HEMATOLOGICAL PARAMETERS IN THE FRESHWATER FISH, LABEO ROHITA
The present investigation was carried out the effect of petrochemical effluent on hematological parameters in freshwater fish, Labeo rohita using the standard method. The petrochemical effluent has the potential to cause...