IN VITRO ACTIVITY OF COLISTIN AGAINST MULTIDRUG RESISTANT GRAM NEGATIVE BACILLI (MDR GNB) ISOLATED FROM VARIOUS CLINICAL SPECIMENS
Journal Title: IJSR-International Journal Of Scientific Research - Year 2018, Vol 8, Issue 4
Abstract
Introduction: Currently colistin is increasingly being used against multidrug resistant gram negative bacteria which include Pseudomonas aeruginosa,,Acinetobacter baumanii, Escherichia coli, Klebsiella pneumoniae & Salmonella enterica. [1] Colistin resistant organisms are reported in various parts of world. Methods: Total 200 MDR GNB isolates were included in the study & tested for their susceptibility to colistin by Kirby Bauer Disc Diffusion Test. Results: Isolates consisted of 64 Escherichia coli,45 Pseudomonas aeruginosa, 44 Klebsiella pneumoniae,32 Citrobacter koseri,13 Acinetobacter baumanii & 2 Proteus mirabilis. Of these, 69 (34.5%) were resistant to Colistin. Colistin resistance in highest number was detected in Escherichia coli isolates obtained from various samples. Conclusion: As colistin resistance is emerging rapidly, measures are necessary to restrict indiscriminate use of antimicrobials & to adhere strictly to the hospital antibiotic policy. It is also the need of an hour that newer antimicrobials get discovered soon to tackle such MDR microorganisms.
Authors and Affiliations
Dr. Ketaki Vyankatesh Kulkarni, Dr. Sandhya S. Kulkarni, Dr. Niranjan Pathak
Keywords
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