In Vitro and In Vivo Hepatoprotective Activity of Madhuca Longifolia L Leaves on Carbon Tetrachloride Induced Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Administration of Madhuca longifolia Methanolic Extract (MLME) and derivative of Madhucic Acid (dMA) a bioactive from it leaves and standard drug silymarin in rats showed significant hepatoprotective action against CCl4 induced hepatotoxicity. Elevated serum markers enzymes of SGOT, SGPT, ALP and serum bilirubin were found to be significantly reduced to near normal levels on treatment of rats with MLME and dMA treated rats. MLME (50 mg/kg) and dMA (5 mg/kg) decreased the cholesterol level and increased TG level. In vitro hepatoprotective activity of the MLME and dMA was evaluated at 50 and 5 μg/ml concentrations against CCl4 (1 %) induced toxicity in freshly isolated rat hepatocytes. The combination of silymarin with MLME and dMA showed better hepatoprotective activity when compared with the standard.
Authors and Affiliations
Triveni S. Inganakal, Shivaraj Inganakal
Keywords
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- EP ID EP395462
- DOI 10.9790/3008-1304011824
- Views 75
- Downloads 0
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