IN VITRO AND IN VIVO TOXICOLOGICAL EVALUATION OF AQUEOUS EXTRACTS FROM BENINESE PLANTS: SENNA SIAMEA LEAVES AND SARCOPCEPHALUS LATIFOLUS STEM ROOTS
Journal Title: International Journal of Pharmacognosy - Year 2017, Vol 4, Issue 2
Abstract
The toxicity of aqueous extracts of S. siamea leaves, S. latifolius roots collected in Benin and their mixture (1/1, w/w), was evaluated on female non pregnant rats, albino wistar genus. They were treated during two weeks, with various extracts administered by oral way at 2000 mg / kg body weight. The biochemical parameters were determinate, histological analysis of the rats was done and the urinary concentration of Neutral Gelatinased Associated Lipocalin (NGAL) was measured. The treatment of the rats with different extracts not caused undesirable effects and deaths during the fourteen day of observation. Significant changes relative of histologycal aspect of hepatocyte and renal cortex as well as significant increases in activity of enzyme serum alanine amino transferases (ALT) and aspartate amino transferases (AST). The aqueous extracts at 2000 mg/kg were disrupted some biochemical parameters. These changes were confirmed by the rate raised from NGAL noted in the urine of the treated rats.
Authors and Affiliations
Alban Gouton Houngbeme et al.
Keywords
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