In -vitro Antiplasmodial Activity and the Chromatogram Profile of Active fraction of Central Borneo-Type Angiopteris evecta Tubers
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 4
Abstract
Angiopteris evecta plant is one of the plants used by people in Central Borneo as antimalarial drug. The study conducted isabout in vitro antiplasmodial activity against the ethanolic extract of A. evecta tubers with the IC50 value of 2.858±0.27µg/mL.The results of the study showed that A. evecta tubers have potential in vitro antiplasmodial activity. Therefore, further study should be conducted to make the fractionation of A. evecta tubers and determine the active fractions of A. evecta tubers as in vitro antiplasmodium. In vitro antiplasmodial activityis based on Candlejar methods on the active fractions of A. evecta tubers using the culture of P. falciparum. The results of the fractionation include three fractions, namely FA, FB, and FC. The in vitro antiplasmodial activities ofFA, FB, and FC are expressed ininhibitory concentration of 50%. The results of probit analysisfrom the triplet tests indicate that the IC50 mean values of FA, FB, and FC were 37.93±1.19; 3.35±0.07; and>250µg/mL, respectively. Based on in vitro antiplasmodial activity,those of FA were categorized as active, of FB were very potential, and of FC were inactive. The three fractions show that the strongest in vitro antiplasmodial activity was the activity of FB. Keywords: Angiopteris evecta, antiplasmodial, in vitro, Plasmodium falciparum, FCR3
Authors and Affiliations
Arnida ,, Wahyono ,, Mustofa ,, R. Asmah Susidarti
Keywords
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