IN VITRO DISSOLUTION ENHANCEMENT OF ALBENDAZOLE BY PREPARATION OF INCLUSION COMPLEXS WITH HP- ß CYCLODEXTRIN
Journal Title: Pharma Science Monitor-An International Journal Pharmaceutical Sciences - Year 2011, Vol 2, Issue 1
Abstract
With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolution rate of albendazole poorly soluble drugs from BCS class II by complexation process. Complexation was prepared using cyclodextrine. Different techniques were employed for preparation of complexation with cyclodextrin like physical mixture, cogrinding, kneading technology, solvent coevaporation. The physical properties of the prepared solid mass of ABZ was characterized by in vitro dissolution studies, UV-V spectroscopy, Fourior transform infrared spectroscopy, differential scanning calorimetry (DSC) and Xray powder differaction spectroscopy. Additionaly, phase solubility studies were performed to support the in vitro dissolution study. The results of Fourior transform infrared spectroscopy shows the compatibility of drug with cyclodextrin, while differential scanning calorimetry (DSC) and X-ray powder differaction spectroscopy showed the confirmation of complexation of cyclodextrin with Abz.
Authors and Affiliations
Vipul P. Patel , Rajesh K. Parikh , Mukesh C. Gohel , Tushar R. Desai , Dipen R. Bhimani , Pravin R. Tirgar
Keywords
Related Articles
- EP ID EP150351
- DOI -
- Views 121
- Downloads 0
RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LOSARTAN POTASSIUM AND ATENOLOL IN TABLET FORMULATION
This work is concerned with application of simple, precise, accurate and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Losartan potassium (LP) and At...
PHARMACOEPIDEMIOLOGY AND PHARMACOTHERAPHY OF ARTHRITIS IN NORTH GUJARAT
Several incidence and prevalence studies of RA have been reported during the last decades, suggesting a considerable variation of the disease occurrence among different populations. This epidemiology study has been don...
Safety of tolfenamic acid following repeated Intramuscular administration in wistar rats.
Tolfenamic acid (TA) is a non-steroidal anti-inflammatory agent of the fenamate sub-group. Safety of Tolfenamic acid (4 mg/kg) after daily intramuscular administration for 14 days was evaluated in wistar rats. Repeated...
A SYSTEMATIC REVIEW ON NATURAL MEDICINE USED FOR THERAPY OF DIABETES MELLITUS OF SOME INDIAN MEDICINAL PLANTS
Diabetes mellitus is one of the world’s major diseases. It currently affects an estimated 143 million people worldwide and the number is growing rapidly. In the India, about 1- 5% population suffer from diabetes or rel...
DEVELOPMENT AND OPTIMIZATION OF AN ECONOMIC METHOD FOR QUANTITATION OF AZITHROMYCIN IN HUMAN PLASMA BY TANDEM MASS SPECTROSCOPY (LCMS/MS) FOR CLINICAL TRIALS
The present study deals with development and optimization of an economic method for quantitation of Azithromycin in human plasma by Tandem Mass Spectroscopy (LCMS/MS) for Clinical studies. Enalapril (stable and economi...