In vitro Effects of Persea americana Aqueous Extracts Against Oxidants and Fe2+Induced Oxidative Stress in Rats’ Pancreas
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 6
Abstract
Received 19 May 2018 Revised 05 June 2018 Accepted 07 June 2018 Published online 07 June 2018 Various mechanisms have been reported to orchestrate the antioxidant properties of bioactive compositions of medicinal plants in the management/treatment of many diseases. In this research, we focused on the antioxidant and anti-lipid peroxidation potential of aqueous extracts of Persea americana. Total phenol content, total flavonoid content, ferric reducing antioxidant property (FRAP), OH- radical scavenging ability, 1, 1-diphenylpicryhydrazyl (DPPH) radical scavenging ability and anti-lipid peroxidation strength of the extracts were estimated using 5 mg/mL. Leaf and seed extracts showed the highest total phenol and flavonoid contents respectively, while the FRAP of the seed was significantly (P < 0.05) higher than others. IC50 values revealed that Peel (IC50 = 0.335 ± 0.067) has the highest DPPH potential while OH- radicals and MDA were significantly (P < 0.05) reduced by the leaf extract in a dose dependent pattern. Characterization of avocado leaf and fruit parts revealed varied concentrations of phenolics (Syringic acid, eugenol, vnillic acid, isoeugenol, guaiacol, phenol, kaempherol, catechin, ρ-hydroxybenzoic acid, ferulic acid, apigenin, naringenin, epigallocatechin, lupeol and epigallocatechin-3-O-gallate). Our findings showed that the aqueous extract of the leaf and fruit parts of avocado pear (P. americana) protected the pancreas from Fe2+ induced lipid peroxidation in vitro which could be attributed to their phenolic compounds and this may be due to their antioxidant activities, Fe2+ chelating ability, radical scavenging strength and reducing power. This research therefore suggests the use of avocado pear as a functional food for the management of oxidative stress related diseases.
Authors and Affiliations
Temitope I. Adelusi, Ganiyu Oboh, Ayodele J. Akinyemi
Keywords
Related Articles
- EP ID EP490866
- DOI 10.26538/tjnpr/v2i6.8
- Views 83
- Downloads 0
Fear and Anxiety Behaviour In Mice Was Attenuated Following Chronic Consumption of Musa paradisiaca L. (Musaceae)
Emotions are delicate phenomenon that can affect the whole livelihood, yet to control them physiologically is quite difficult perhaps owing to the paucity in connections between limbic system and neocortex. Many people h...
In Vivo Antiplasmodial and Toxicological Effects of Extracts of Fruit Pulp of Chrysophyllum albidium G. Don (Sapotaceae)
Plant parts of Chrysophyllum albidium is reported to possess antimalarial properties. However, knowledge gaps still exist in the antimalarial efficacy and safety of some solvent fractions of the fruit pulp. The aim of t...
Processing and Evaluation of Locally Sourced Kaolin for Pharmaceutical Production
Received 03 July 2018 Revised 05 August 2018 Accepted 09 August 2018 Published online 10 August 2018 Cheaper and readily available natural clay deposits in Nigeria, may serve as good sources of pharmaceutical raw materi...
Characterization of Acid Treated Porcine Mucin and its Effects on Bioadhesion
Received 10 January 2018 Revised 28 January 2018 Accepted 03 February 2018 Published online 07 February 2018 The study aimed at determining the effect of acid modification on the physicochemical and bioadhesive properti...
Preparation and Comparative Analysis of Neem and Dehydrated Castor Seed Oil Alkyd Resin Paint Coatings
Received 25 September 2018 Revised 09 October 2018 Accepted 18 October 2018 Published online 23 October 2018 Coatings such as paint are made up of four important components; pigments, binders, solvent and additives. Glo...