In vitro efficacy of fosfomycin against clinical strains
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2014, Vol 4, Issue 2
Abstract
Objectives: Fosfomycin is an alternative drug for treatment of uncomplicated urinary tract infections. This study aimed to investigate in vitro activity of osfomycin against methicillin-resistant Staphylococcus aureus (MRSA), methicillin resistant coagulase negative staphylococci (MRCoNS), vancomycin-resistant Enterococcus faecium (VRE. faecium),Escherichia coli, Klebsiella pneumoniae, and Enterobacter isolates. Methods:Clinical isolates of MRSA, MRCoNS,E. coli, K. pneumoniae and Enterobacter spp. and VRE isolates which were isolated from rectal swaps were identified with Vitek 2 Compact (Biomeriux, France) and BD Phoenix (BD USA) auto mated systems. The Kirby-Bauer disc diffusion method was used to determine the susceptibility to fosfomycin. Results:All the MRSA (n=40), MRCoNS (n=40), and VRE. faecium (n=62) isolates were susceptible to fosfomycin. The fosfomycin susceptibility rates for E. coli, K. pneumoniae, and Enterobacter spp.were 97.5% (39 of 40), 97.3% (36 of 37), and 86.9% (20 of 23), respectively. One (2.7%) isolate of K. pneumoniae and three (13.1%) isolates of Enterobacter spp. showed intermediate susceptibility to fosfomycin. Resistance to fosfomycin was detected in only one (2.5%) isolate of E. coli. Conclusion: Based on the results of our study, fosfomycin is highly active against a collection of several gram-positive and gram-negative bacteria, including multidrug resistant isolates, and is an alternative drug in the treatment option.J Microbiol Infect Dis 2014;4(2): 55-58 Key words: Fosfomycin, gram-positive bacteria, gram-negative bacteria, antimicrobial agent
Authors and Affiliations
Adil Karadağ, Yeliz Çaycı, Kemal Bilgin, Murat Günaydın, Cafer Eroğlu
Keywords
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- EP ID EP110585
- DOI 10.5799/ahinjs.02.2014.02.0127
- Views 144
- Downloads 0
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