In Vitro Evaluation of the Antimicrobial and Antioxidant Activity of Hibiscus Sabdariffa L
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Prevalence Of Resistant Microbial Strains Is Increasing With Time; Due To The Extensive And Indiscriminate Use Of The Broad Spectrum Antimicrobials That Rendered The Current Used Antimicrobial Agents Insufficient To Control Some Microbial Infections. The Present Study Was Aimed To Investigate The Antimicrobial And Antioxidant Potential Of Methanolic Extract Of The Medicinal Plant Hibiscus Sabdariffa L. The Agar Well Diffusion Technique Was Used To Determine The Antimicrobial Activity Of Methanolic Extract Of Hibiscus Sabdariffa L And The Antioxidant Activity Was Determined Throughthe DPPH Radical Scavenging Assay. The Methanolic Extract Of Hibiscus Sabdariffa L Was Examined Against Six Reference Bacterial Strains, One Fungal, And One Parasitic Clinical Isolate Which Include : Escherichia Coli (ATCC 25922) Pseudomonas Aeruginosa (ATCC27853), Klebsiella Pneumoniae (ATCC 15380), Salmonella Typhi (ATCC), Bacillus Subtilis (NCTC 8236), Staphylococcus Aureus (ATCC 25923), Candida Albicans (ATCC 7596) And Giardia Lamblia. The Result Of The Preliminary Screening Extract Showed Activity Against All Microorganisms Tested The Inhibition Zones Ranged From 20 To 25 Mm. The Minimum Inhibitory Concentrations Were Determined For The Extract Against The Selected Reference Strains. The Methanolic Extract Of The Hibiscus Sabdariffa L Screened For Antigiardial Activity Against (G. Lamblia) Trophozoites In Vitro Showed Antigiardial Activity With Inhibition Concentrations (IC50) More Than 180μg/Ml. The Methanolic Extract Of Hibiscus Sabdariffa L Revealed That The Selected Plant Had A Significant Potential Effect Inhibiting The Growth Of Bacterial, Fungal, Parasitic Strains In Addition To Its Radical Scavenging Activity.
Authors and Affiliations
Mohammed Abdalbagi Dafalla Youns, Ahmed Ibrahim Hashim, Suliman Ismail Suliman, Ahmed Bakheet Abd Alla
Keywords
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- EP ID EP370461
- DOI 10.9790/0853-1704036974.
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