In vitro experimental models to study the efficiency of the placental barrier for environmental toxicants: tumor cell lines versus trophoblast primary cells.
Journal Title: Biomedicine & Prevention - Year 2018, Vol 2018, Issue 1
Abstract
Mammalian development is characterized by an evolutionary innovation represented by the trophoblast, which contributes to the formation of the placenta, a transient organ regulating exchange of nutrients, gases and waste material between the mother and the developing fetus. Survival of the fetus relies on proper development of the placenta, which is also responsible for the formation of a selective barrier that protects the embryo, at least in part, from xenobiotics. The barrier function of the placenta has been investigated for viral/bacterial transfer and for drug and nanoparticulate matter access to the fetal compartment. Since species specific structural differences exist, results on the ability of xenobiotics to access the placental barrier obtained from animal studies cannot be automatically transposed to humans. However, in vivo studies on human placenta permeability cannot be performed, and the use of in vitro alternative methods are in great need. In the present mini-review we will present and critically discuss the available in vitro methods that have been so far developed and present a new model system that we have recently established.
Authors and Affiliations
Luisa Campagnolo, Valentina Lacconi, Micol Massimiani, Andrea Magrini, Antonio Pietroiusti
Keywords
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- EP ID EP336300
- DOI 10.19252/00000009D
- Views 154
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