In Vitro, Pharmacokinetic, Pharmacodynamic, and Safety Comparisons of Single and Combined Administration of Tiotropium and Salmeterol in COPD Patients Using Different Dry Powder Inhalers

Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 4

Abstract

The online version of this article (doi:10.1208/s12248-015-9751-7) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Stephen T. Horhota, Jan A. van Noord, Cynthia B. Verkleij, Loek J. Bour, Ashish Sharma, Michael Trunk, Piet J. G. Cornelissen

Keywords

Related Articles

Recent Advances in Blood–Brain Barrier Disruption as a CNS Delivery Strategy

The blood–brain barrier (BBB) is a complex functional barrier composed of endothelial cells, pericytes, astrocytic endfeets and neuronal cells. This highly organized complex express a selective permeability for m...

Bioequivalence Requirements in the European Union: Critical Discussion

The aim of the present paper is to summarize the revised European Union (EU) Guideline on the Investigation of Bioequivalence and to discuss critically with respect to previous European requirements and present US Food a...

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

The etiology of most human diseases involves complicated interactions of multiple environmental factors with individual genetic background which is initially generated early in human life, for example, during the process...

A thermogravimetric analysis of non-polymeric pharmaceutical plasticizers: Kinetic analysis, method validation, and thermal stability evaluation

Four non-polymeric plasticizers, propylene glycol, diethyl phthalate, triacetin, and glycerin have been subjected to rising temperature thermogravimetry for kinetic analysis and vaporization-based thermal stability evalu...

Epidermal Growth Factor Receptor-Targeted Gelatin-Based Engineered Nanocarriers for DNA Delivery and Transfection in Human Pancreatic Cancer Cells

Type B gelatin-based engineered nanocarrier systems (GENS) have been used over the last several years as a non-condensing systemic and oral DNA delivery system. In this study, we have modified the surface of GENS with ep...

Download PDF file
  • EP ID EP680971
  • DOI  10.1208/s12248-015-9751-7
  • Views 55
  • Downloads 0

How To Cite

Stephen T. Horhota, Jan A. van Noord, Cynthia B. Verkleij, Loek J. Bour, Ashish Sharma, Michael Trunk, Piet J. G. Cornelissen (2015). In Vitro, Pharmacokinetic, Pharmacodynamic, and Safety Comparisons of Single and Combined Administration of Tiotropium and Salmeterol in COPD Patients Using Different Dry Powder Inhalers. The AAPS Journal, 17(4), -. https://europub.co.uk./articles/-A-680971